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Nuclear magnetic relaxation study of hindered rotational diffusion in gels

Claeys, Ivan L. and Arnold, Frances H. (1989) Nuclear magnetic relaxation study of hindered rotational diffusion in gels. AIChE Journal, 35 (2). pp. 335-338. ISSN 0001-1541. http://resolver.caltech.edu/CaltechAUTHORS:20180822-140906987

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Abstract

Polymeric gels are widely used in biotechnology, primarily for purification purposes in separation processes, but also as matrices for the physical entrapment of cells and macromolecules, or for the covalent attachment of enzymes and ligands (Mosbach. 1976). The restricted diffusion of molecules through these gels is an important concern in the design and operation of chromatographic separations, bioreactors, electrophoretic media, etc. Yet the fundamental aspects of the interactions between the gel fibers and the diffusing substances are still poorly understood. In this research note, nuclear magnetic relaxation is shown to be a useful probe pf the tumbling motion of molecules embedded in a gel. The technique is applied to study the rotational diffusion of cyclic guanosine monophosphate (cGMP) in polyacrylamide and agarose matrices.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/aic.690350223DOIArticle
ORCID:
AuthorORCID
Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 1989 American Institute of Chemical Engineers. Manuscript received: 18 July 1988. Manuscript revised: 11 October 1988.
Record Number:CaltechAUTHORS:20180822-140906987
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180822-140906987
Official Citation:Claeys, I. L. and Arnold, F. H. (1989), Nuclear magnetic relaxation study of hindered rotational diffusion in gels. AIChE J., 35: 335-338. doi:10.1002/aic.690350223
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89049
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:22 Aug 2018 21:44
Last Modified:22 Aug 2018 21:44

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