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Engineering enzymes for non-aqueous solvents

Arnold, Frances H. (1990) Engineering enzymes for non-aqueous solvents. Trends in Biotechnology, 8 (9). pp. 244-249. ISSN 0167-7799. https://resolver.caltech.edu/CaltechAUTHORS:20180822-160257032

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Abstract

Enzymes may be redesigned to permit catalysis in non-aqueous solvents by engineering their amino acid sequences, thereby altering their physical and chemical properties to suit the new solvent environment. The interactions that contribute to protein stability in non-aqueous solvents are discussed in the context of attempting to identify possible approaches to constructing enzymes which exhibit enhanced stability in non-aqueous media. These approaches are illustrated by several examples where protein engineering has resulted in enzymes that are better suited for catalysis in organic solvents.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/0167-7799(90)90186-2DOIArticle
ORCID:
AuthorORCID
Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 1990 Published by Elsevier Ltd.
Issue or Number:9
Record Number:CaltechAUTHORS:20180822-160257032
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180822-160257032
Official Citation:Frances H. Arnold, Engineering enzymes for non-aqueous solvents, Trends in Biotechnology, Volume 8, 1990, Pages 244-249, ISSN 0167-7799, https://doi.org/10.1016/0167-7799(90)90186-2. (http://www.sciencedirect.com/science/article/pii/0167779990901862)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89066
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 Aug 2018 14:02
Last Modified:03 Oct 2019 20:12

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