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Directed evolution of biocatalysts

Arnold, Frances H. and Volkov, Alexander A. (1999) Directed evolution of biocatalysts. Current Opinion in Chemical Biology, 3 (1). pp. 54-59. ISSN 1367-5931. doi:10.1016/S1367-5931(99)80010-6.

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Directed evolution is being used increasingly in academic and industrial laboratories to modify and improve important biocatalysts. Significant advances during this period of review include compartmentalization of genes and the in vitro translation apparatus in emulsions, as well as several impressive demonstrations of catalyst improvement. Shuffling of homologous genes offers a new way to utilize natural diversity in the evolution of novel catalysts.

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Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 1999 Elsevier Science Ltd. The authors wish to acknowledge support for directed evolution research provided by the Office of Naval Research and the Army Research Office, USA.
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Office of Naval Research (ONR)UNSPECIFIED
Army Research Office (ARO)UNSPECIFIED
Issue or Number:1
Record Number:CaltechAUTHORS:20180822-160718852
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Official Citation:Frances H Arnold, Alexander A Volkov, Directed evolution of biocatalysts, Current Opinion in Chemical Biology, Volume 3, Issue 1, 1999, Pages 54-59, ISSN 1367-5931, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89067
Deposited By: Tony Diaz
Deposited On:23 Aug 2018 14:00
Last Modified:16 Nov 2021 00:32

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