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Metal-mediated protein stabilization

Arnold, Frances H. and Zhang, Ji-Hu (1994) Metal-mediated protein stabilization. Trends in Biotechnology, 12 (5). pp. 189-192. ISSN 0167-7799. http://resolver.caltech.edu/CaltechAUTHORS:20180822-161848179

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Abstract

Metal binding provides several useful routes to protein stabilization. Metal chelation by binding sites engineered into proteins can increase thermal stability, conformational stability and reduce proteolytic degradation. As few as two coordinating ligands, if properly positioned on the protein surface, can form chelating sites suitable for metal binding and stabilization. Thus, this approach is relatively easy to implement and can be applied to a wide range of proteins.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/0167-7799(94)90081-7DOIArticle
ORCID:
AuthorORCID
Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 1994 Published by Elsevier Ltd.
Record Number:CaltechAUTHORS:20180822-161848179
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180822-161848179
Official Citation:Frances H. Arnold, Ji-Hu Zhang, Metal-mediated protein stabilization, Trends in Biotechnology, Volume 12, Issue 5, 1994, Pages 189-192, ISSN 0167-7799, https://doi.org/10.1016/0167-7799(94)90081-7. (http://www.sciencedirect.com/science/article/pii/0167779994900817)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89069
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 Aug 2018 13:58
Last Modified:23 Aug 2018 13:58

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