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Metal-mediated protein stabilization

Arnold, Frances H. and Zhang, Ji-Hu (1994) Metal-mediated protein stabilization. Trends in Biotechnology, 12 (5). pp. 189-192. ISSN 0167-7799. doi:10.1016/0167-7799(94)90081-7.

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Metal binding provides several useful routes to protein stabilization. Metal chelation by binding sites engineered into proteins can increase thermal stability, conformational stability and reduce proteolytic degradation. As few as two coordinating ligands, if properly positioned on the protein surface, can form chelating sites suitable for metal binding and stabilization. Thus, this approach is relatively easy to implement and can be applied to a wide range of proteins.

Item Type:Article
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Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 1994 Published by Elsevier Ltd.
Issue or Number:5
Record Number:CaltechAUTHORS:20180822-161848179
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Official Citation:Frances H. Arnold, Ji-Hu Zhang, Metal-mediated protein stabilization, Trends in Biotechnology, Volume 12, Issue 5, 1994, Pages 189-192, ISSN 0167-7799, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89069
Deposited By: Tony Diaz
Deposited On:23 Aug 2018 13:58
Last Modified:16 Nov 2021 00:32

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