Schmidt-Dannert, Claudia and Arnold, Frances H. (1999) Directed evolution of industrial enzymes. Trends in Biotechnology, 17 (4). pp. 135-136. ISSN 0167-7799. doi:10.1016/s0167-7799(98)01283-9. https://resolver.caltech.edu/CaltechAUTHORS:20180823-144310884
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Abstract
Directed evolution has emerged in just a few years as one of the most effective approaches to adapting biocatalysts to the performance requirements of industrial and medical applications. Directed evolution mimics the processes of Darwinian evolution in a test tube, combining random mutagenesis and/or recombination with screening or selection for enzyme variants that have the desired properties1. A recent conference* that convened practitioners from industry and academia surveyed current efforts and highlighted the rapid progress the field has enjoyed. In addition to impressive demonstrations of enzyme engineering, there were a variety of challenging problems and approaches to laboratory evolution.
| Item Type: | Article | ||||||
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| Additional Information: | © 1999 Published by Elsevier. | ||||||
| Subject Keywords: | directed evolution; DNA shuffling; random mutagenesis; high-throughput screening; enzymes; biocatalysis | ||||||
| Issue or Number: | 4 | ||||||
| DOI: | 10.1016/s0167-7799(98)01283-9 | ||||||
| Record Number: | CaltechAUTHORS:20180823-144310884 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180823-144310884 | ||||||
| Official Citation: | Claudia Schmidt-Dannert, Frances H Arnold, Directed evolution of industrial enzymes, Trends in Biotechnology, Volume 17, Issue 4, 1999, Pages 135-136, ISSN 0167-7799, https://doi.org/10.1016/S0167-7799(98)01283-9. (http://www.sciencedirect.com/science/article/pii/S0167779998012839) | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 89103 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | George Porter | ||||||
| Deposited On: | 23 Aug 2018 22:53 | ||||||
| Last Modified: | 16 Nov 2021 00:32 |
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