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Directed evolution of industrial enzymes

Schmidt-Dannert, Claudia and Arnold, Frances H. (1999) Directed evolution of industrial enzymes. Trends in Biotechnology, 17 (4). pp. 135-136. ISSN 0167-7799. doi:10.1016/s0167-7799(98)01283-9.

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Directed evolution has emerged in just a few years as one of the most effective approaches to adapting biocatalysts to the performance requirements of industrial and medical applications. Directed evolution mimics the processes of Darwinian evolution in a test tube, combining random mutagenesis and/or recombination with screening or selection for enzyme variants that have the desired properties1. A recent conference* that convened practitioners from industry and academia surveyed current efforts and highlighted the rapid progress the field has enjoyed. In addition to impressive demonstrations of enzyme engineering, there were a variety of challenging problems and approaches to laboratory evolution.

Item Type:Article
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Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 1999 Published by Elsevier.
Subject Keywords:directed evolution; DNA shuffling; random mutagenesis; high-throughput screening; enzymes; biocatalysis
Issue or Number:4
Record Number:CaltechAUTHORS:20180823-144310884
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Official Citation:Claudia Schmidt-Dannert, Frances H Arnold, Directed evolution of industrial enzymes, Trends in Biotechnology, Volume 17, Issue 4, 1999, Pages 135-136, ISSN 0167-7799, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89103
Deposited By: George Porter
Deposited On:23 Aug 2018 22:53
Last Modified:16 Nov 2021 00:32

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