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Loss of the E3 Ubiquitin Ligase SKP2 Limits De Oncogenic Potential of Notch in T-Cell Lymphoblastic Leukemia

Rodriguez-Rodriguez, Sonia and Wang, Lin and Zhang, Hujia and Mehrotra, Purvi and Zollman, Amy and Kaplan, Mark and Sandusky, George and Chiang, Mark and Mulloy, James and Wunderlich, Mark and Palmer, Joycelynne and Yui, Mary and Cardoso, Angelo and Carlesso, Nadia (2018) Loss of the E3 Ubiquitin Ligase SKP2 Limits De Oncogenic Potential of Notch in T-Cell Lymphoblastic Leukemia. Experimental Hematology, 64 (S1). S98. ISSN 0301-472X. https://resolver.caltech.edu/CaltechAUTHORS:20180904-084305534

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Abstract

Despite marked clinical successes in the treatment of childhood T-ALL, leukemia relapse, refractory disease and induction failure (around 30% of patients) remain significant clinical problems. New insights in the molecular alterations of ALL have revealed new molecular targets, such as activating mutations of Notch1 (N1), identified in more than 50% of T-ALL patients. However, disruption of N1 signaling by gamma-secretase inhibitors failed to fulfill its clinical promise. Furthermore, little is known about N1 downstream mediators that can be potential therapeutic targets in T-ALL.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.exphem.2018.06.133DOIArticle
https://www.exphem.org/article/S0301-472X(18)30428-4/abstractPublisherArticle
ORCID:
AuthorORCID
Mehrotra, Purvi0000-0001-9369-5013
Yui, Mary0000-0002-3136-2181
Additional Information:© 2018 Elsevier B.V. Available online 22 August 2018.
Issue or Number:S1
Record Number:CaltechAUTHORS:20180904-084305534
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180904-084305534
Official Citation:Sonia Rodriguez-Rodriguez, Lin Wang, Hujia Zhang, Purvi Mehrotra, Amy Zollman, Mark Kaplan, George Sandusky, Mark Chiang, James Mulloy, Mark Wunderlich, Joycelynne Palmer, Mary Yui, Angelo Cardoso, Nadia Carlesso, 3150 - Loss of the E3 Ubiquitin Ligase SKP2 Limits De Oncogenic Potential of Notch in T-Cell Lymphoblastic Leukemia, Experimental Hematology, Volume 64, Supplement, 2018, Page S98, ISSN 0301-472X, https://doi.org/10.1016/j.exphem.2018.06.133. (http://www.sciencedirect.com/science/article/pii/S0301472X18304284)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89347
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:04 Sep 2018 17:00
Last Modified:09 Mar 2020 13:19

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