A Caltech Library Service

Compensation for air voids in photoacoustic computed tomography image reconstruction

Matthews, Thomas P. and Li, Lei and Wang, Lihong V. and Anastasio, Mark A. (2016) Compensation for air voids in photoacoustic computed tomography image reconstruction. In: Photons Plus Ultrasound: Imaging and Sensing 2016. Proceedings of SPIE. No.9708. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 970841. ISBN 9781628419429.

[img] PDF - Published Version
See Usage Policy.


Use this Persistent URL to link to this item:


Most image reconstruction methods in photoacoustic computed tomography (PACT) assume that the acoustic properties of the object and the surrounding medium are homogeneous. This can lead to strong artifacts in the reconstructed images when there are significant variations in sound speed or density. Air voids represent a particular challenge due to the severity of the differences between the acoustic properties of air and water. In whole-body small animal imaging, the presence of air voids in the lungs, stomach, and gastrointestinal system can limit image quality over large regions of the object. Iterative reconstruction methods based on the photoacoustic wave equation can account for these acoustic variations, leading to improved resolution, improved contrast, and a reduction in the number of imaging artifacts. However, the strong acoustic heterogeneities can lead to instability or errors in the numerical wave solver. Here, the impact of air voids on PACT image reconstruction is investigated, and procedures for their compensation are proposed. The contributions of sound speed and density variations to the numerical stability of the wave solver are considered, and a novel approach for mitigating the impact of air voids while reducing the computational burden of image reconstruction is identified. These results are verified by application to an experimental phantom.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
Li, Lei0000-0001-6164-2646
Wang, Lihong V.0000-0001-9783-4383
Anastasio, Mark A.0000-0002-3192-4172
Additional Information:© 2016 Society of Photo-Optical Instrumentation Engineers. This work was supported in part by NIH awards CA1744601 and EB01696301.
Funding AgencyGrant Number
Subject Keywords:photoacoustic computed tomography, image reconstruction, acoustic heterogeneity
Series Name:Proceedings of SPIE
Issue or Number:9708
Record Number:CaltechAUTHORS:20180905-090249745
Persistent URL:
Official Citation:Thomas P. Matthews, Thomas P. Matthews, Lei Li, Lei Li, Lihong V. Wang, Lihong V. Wang, Mark A. Anastasio, Mark A. Anastasio, } "Compensation for air voids in photoacoustic computed tomography image reconstruction", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 970841 (15 March 2016); doi: 10.1117/12.2213307;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89378
Deposited By: Tony Diaz
Deposited On:05 Sep 2018 16:20
Last Modified:16 Nov 2021 00:34

Repository Staff Only: item control page