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Detecting both melanoma depth and volume in vivo with a handheld photoacoustic probe

Zhou, Yong and Li, Guo and Zhu, Liren and Li, Chiye and Cornelius, Lynn A. and Wang, Lihong V. (2016) Detecting both melanoma depth and volume in vivo with a handheld photoacoustic probe. In: Photons Plus Ultrasound: Imaging and Sensing 2016. No.9708. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 970806. ISBN 9781628419429. https://resolver.caltech.edu/CaltechAUTHORS:20180905-095437537

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Abstract

We applied a linear-array-based photoacoustic probe to detect the tumor depth and volume of melanin-containing melanoma in nude mice in vivo. We demonstrated the ability of this linear-array-based system to measure both the depth and volume of melanoma through phantom, ex vivo, and in vivo experiments. The volume detection ability also enables us to accurately calculate the rate of growth of the tumor, which is important in quantifying tumor activity. Our results show that this system can be used for clinical melanoma diagnosis and treatment at the bedside.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.2213245DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2016 Society of Photo-Optical Instrumentation Engineers. The authors would like to thank Prof. James Ballard for manuscript editing. This work was sponsored in part by National Institutes of Health grants DP1 EB016986 (NIH Director’s Pioneer Award), R01 CA186567 (NIH Director’s Transformative Research Award), R01 EB016963, S10 RR026922, and R01 CA159959. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 CA186567
NIHR01 EB016963
NIHS10 RR026922
NIHR01 CA159959
Subject Keywords:Handheld, photoacoustic microscope, melanoma, depth, volume, rate of growth
Issue or Number:9708
Record Number:CaltechAUTHORS:20180905-095437537
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180905-095437537
Official Citation:Yong Zhou, Yong Zhou, Guo Li, Guo Li, Liren Zhu, Liren Zhu, Chiye Li, Chiye Li, Lynn A. Cornelius, Lynn A. Cornelius, Lihong V. Wang, Lihong V. Wang, } "Detecting both melanoma depth and volume in vivo with a handheld photoacoustic probe", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 970806 (15 March 2016); doi: 10.1117/12.2213245; https://doi.org/10.1117/12.2213245
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89381
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 Sep 2018 20:53
Last Modified:03 Oct 2019 20:15

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