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Vascular elastic photoacoustic tomography in humans

Hai, Pengfei and Zhou, Yong and Liang, Jinyang and Li, Chiye and Wang, Lihong V. (2016) Vascular elastic photoacoustic tomography in humans. In: Photons Plus Ultrasound: Imaging and Sensing 2016. Proceedings of SPIE. No.9708. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 970803. ISBN 9781628419429.

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Quantification of vascular elasticity can help detect thrombosis and prevent life-threatening conditions such as acute myocardial infarction or stroke. Here, we propose vascular elastic photoacoustic tomography (VE-PAT) to measure vascular elasticity in humans. VE-PAT was developed by incorporating a linear-array-based photoacoustic computed tomography system with a customized compression stage. By measuring the deformation of blood vessels under uniaxial loading, VE-PAT was able to quantify the vascular compliance. We first demonstrated the feasibility of VE-PAT in blood vessel phantoms. In large vessel phantoms, VE-PAT detected a decrease in vascular compliance due to simulated thrombosis, which was validated by a standard compression test. In small blood vessel phantoms embedded 3 mm deep in gelatin, VE-PAT detected elasticity changes at depths that are difficult to image using other elasticity imaging techniques. We then applied VE-PAT to assess vascular compliance in a human subject and detected a decrease in vascular compliance when an occlusion occurred downstream from the measurement point, demonstrating the potential of VE-PAT in clinical applications such as detection of deep venous thrombosis.

Item Type:Book Section
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Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2016 Society of Photo-Optical Instrumentation Engineers. We thank Alejandro Garcia-Uribe for his assistance in human experiments and Professor James Ballard for a close reading of this paper. This work was sponsored by the National Institutes of Health Grants DP1 EB016986 (NIH Director’s Pioneer Award), R01 CA186567 (NIH Director’s Transformative Research Award), and S10 RR026922. L. V. Wang has a financial interest in Endra, Inc., and Microphotoacoustics, Inc., which, however, did not support this work.
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 CA186567
NIHS10 RR026922
Subject Keywords:photoacoustic tomography, vascular elastography, vascular elasticity, thrombosis
Series Name:Proceedings of SPIE
Issue or Number:9708
Record Number:CaltechAUTHORS:20180905-100350169
Persistent URL:
Official Citation:Pengfei Hai, Pengfei Hai, Yong Zhou, Yong Zhou, Jinyang Liang, Jinyang Liang, Chiye Li, Chiye Li, Lihong V. Wang, Lihong V. Wang, } "Vascular elastic photoacoustic tomography in humans", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 970803 (15 March 2016); doi: 10.1117/12.2219700;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89382
Deposited By: Tony Diaz
Deposited On:05 Sep 2018 20:53
Last Modified:03 Oct 2019 20:15

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