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Hybridized wavefront shaping for high-speed, high-efficiency focusing through dynamic diffusive media

Hemphill, Ashton S. and Tay, Jian Wei and Wang, Lihong V. (2016) Hybridized wavefront shaping for high-speed, high-efficiency focusing through dynamic diffusive media. Journal of Biomedical Optics, 21 (12). Art. No. 121502. ISSN 1083-3668. PMCID PMC5019185. doi:10.1117/1.JBO.21.12.121502.

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One of the prime limiting factors of optical imaging in biological applications is the diffusion of light by tissue, which prevents focusing at depths greater than the optical diffusion limit (typically ∼1  mm). To overcome this challenge, wavefront shaping techniques that use a spatial light modulator (SLM) to correct the phase of the incident wavefront have recently been developed. These techniques are able to focus light through scattering media beyond the optical diffusion limit. However, the low speeds of typically used liquid crystal SLMs limit the focusing speed. Here, we present a method using a digital micromirror device (DMD) and an electro-optic modulator (EOM) to measure the scattering-induced aberrations, and using a liquid crystal SLM to apply the correction to the illuminating wavefront. By combining phase modulation from an EOM with the DMD’s ability to provide selective illumination, we exploit the DMD’s higher refresh rate for phase measurement. We achieved focusing through scattering media in less than 8 ms, which is sufficiently short for certain in vivo applications, as it is comparable to the speckle correlation time of living tissue.

Item Type:Article
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URLURL TypeDescription CentralArticle
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2016 Society of Photo-Optical Instrumentation Engineers. Paper 160172SSPR received Mar. 18, 2016; accepted for publication May 17, 2016; published online Sep. 14, 2016. We thank Jinyang Liang for discussions regarding SLM and DMD alignment, Yan Liu for discussion regarding the dynamic diffusive media experiment, and Seema Dahlheimer for editing the manuscript. This work was supported in part by the National Institute of Health grants DP1 EB016986 (NIH Director’s Pioneer Award) and R01 CA186567 (NIH Director’s Transformative Research Award). L.V.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 CA186567
Subject Keywords:high-speed wavefront shaping; wavefront shaping; active or adaptive optics; dynamic media; turbid media
Issue or Number:12
PubMed Central ID:PMC5019185
Record Number:CaltechAUTHORS:20180905-104549630
Persistent URL:
Official Citation:Ashton S. Hemphill, Ashton S. Hemphill, Jian Wei Tay, Jian Wei Tay, Lihong V. Wang, Lihong V. Wang, } "Hybridized wavefront shaping for high-speed, high-efficiency focusing through dynamic diffusive media," Journal of Biomedical Optics 21(12), 121502 (14 September 2016).
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89386
Deposited By: Tony Diaz
Deposited On:05 Sep 2018 20:48
Last Modified:16 Nov 2021 00:34

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