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Iterative image reconstruction in elastic inhomogenous media with application to transcranial photoacoustic tomography

Poudel, Joemini and Matthews, Thomas P. and Mitsuhashi, Kenji and Garcia-Uribe, Alejandro and Wang, Lihong V. and Anastasio, Mark A. (2017) Iterative image reconstruction in elastic inhomogenous media with application to transcranial photoacoustic tomography. In: Medical Imaging 2017: Ultrasonic Imaging and Tomography. Proceedings of SPIE. No.10139. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 101390C.

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Photoacoustic computed tomography (PACT) is an emerging computed imaging modality that exploits optical contrast and ultrasonic detection principles to form images of the photoacoustically induced initial pressure distribution within tissue. The PACT reconstruction problem corresponds to a time-domain inverse source problem, where the initial pressure distribution is recovered from the measurements recorded on an aperture outside the support of the source. A major challenge in transcranial PACT brain imaging is to compensate for aberrations in the measured data due to the propagation of the photoacoustic wavefields through the skull. To properly account for these effects, a wave equation-based inversion method should be employed that can model the heterogeneous elastic properties of the medium. In this study, an iterative image reconstruction method for 3D transcranial PACT is developed based on the elastic wave equation. To accomplish this, a forward model based on a finite-difference time-domain discretization of the elastic wave equation is established. Subsequently, gradient-based methods are employed for computing penalized least squares estimates of the initial source distribution that produced the measured photoacoustic data. The developed reconstruction algorithm is validated and investigated through computer-simulation studies.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
Wang, Lihong V.0000-0001-9783-4383
Anastasio, Mark A.0000-0002-3192-4172
Additional Information:© 2017 Society of Photo-Optical Instrumentation Engineers. This work was supported in part by NIH awards EB01696301, 5T32EB01485505 and NSF award DMS1614305.
Funding AgencyGrant Number
NIH Predoctoral Fellowship5T32EB01485505
Subject Keywords:Photoacoustic computed tomography, image reconstruction, transcranial imaging, elastic wave equation
Series Name:Proceedings of SPIE
Issue or Number:10139
Record Number:CaltechAUTHORS:20180905-111750969
Persistent URL:
Official Citation:Joemini Poudel, Joemini Poudel, Thomas P. Matthews, Thomas P. Matthews, Kenji Mitsuhashi, Kenji Mitsuhashi, Alejandro Garcia-Uribe, Alejandro Garcia-Uribe, Lihong V. Wang, Lihong V. Wang, Mark A. Anastasio, Mark A. Anastasio, } "Iterative image reconstruction in elastic inhomogenous media with application to transcranial photoacoustic tomography", Proc. SPIE 10139, Medical Imaging 2017: Ultrasonic Imaging and Tomography, 101390C (13 March 2017); doi: 10.1117/12.2254141;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89390
Deposited By: Tony Diaz
Deposited On:05 Sep 2018 20:32
Last Modified:03 Oct 2019 20:15

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