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Focusing light through biological tissue and tissue-mimicking phantoms up to 9.6 cm in thickness with digital optical phase conjugation

Shen, Yuecheng and Liu, Yan and Ma, Cheng and Wang, Lihong V. (2016) Focusing light through biological tissue and tissue-mimicking phantoms up to 9.6 cm in thickness with digital optical phase conjugation. Journal of Biomedical Optics, 21 (8). Art. No. 085001. ISSN 1083-3668. PMCID PMC4982119. http://resolver.caltech.edu/CaltechAUTHORS:20180905-143750704

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Abstract

Optical phase conjugation (OPC)-based wavefront shaping techniques focus light through or within scattering media, which is critically important for deep-tissue optical imaging, manipulation, and therapy. However, to date, the sample thickness in OPC experiments has been limited to only a few millimeters. Here, by using a laser with a long coherence length and an optimized digital OPC system that can safely deliver more light power, we focused 532-nm light through tissue-mimicking phantoms up to 9.6 cm thick, as well as through ex vivo chicken breast tissue up to 2.5 cm thick. Our results demonstrate that OPC can be achieved even when photons have experienced on average 1000 scattering events. The demonstrated penetration of nearly 10 cm (∼100 transport mean free paths) has never been achieved before by any optical focusing technique, and it shows the promise of OPC for deep-tissue noninvasive optical imaging, manipulation, and therapy.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/1.JBO.21.8.085001DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982119/PubMed CentralArticle
ORCID:
AuthorORCID
Shen, Yuecheng0000-0003-1990-8142
Liu, Yan0000-0002-5837-4908
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2016 Society of Photo-Optical Instrumentation Engineers. Paper 160364R received Jun. 2, 2016; accepted for publication Jul. 25, 2016; published online Aug. 12, 2016. The authors thank Dr. Puxiang Lai for helpful discussions, and Prof. James Ballard for proofreading the article. This work was sponsored in part by the National Institutes of Health Grant Nos. DP1 EB016986 and R01 CA186567.
Funders:
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 CA186567
Subject Keywords:focusing light through scattering media; adaptive optics; wavefront shaping; optical phase conjugation; holographic interferometry; turbid media
PubMed Central ID:PMC4982119
Record Number:CaltechAUTHORS:20180905-143750704
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180905-143750704
Official Citation:Yuecheng Shen, Yuecheng Shen, Yan Liu, Yan Liu, Cheng Ma, Cheng Ma, Lihong V. Wang, Lihong V. Wang, } "Focusing light through biological tissue and tissue-mimicking phantoms up to 9.6 cm in thickness with digital optical phase conjugation," Journal of Biomedical Optics 21(8), 085001 (12 August 2016). https://doi.org/10.1117/1.JBO.21.8.085001
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89400
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 Sep 2018 16:44
Last Modified:06 Sep 2018 16:44

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