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Clinical photoacoustic computed tomography of the human breast in vivo within a single breath hold

Lin, Li and Hu, Peng and Shi, Junhui and Appleton, Catherine M. and Maslov, Konstantin and Wang, Lihong V. (2018) Clinical photoacoustic computed tomography of the human breast in vivo within a single breath hold. In: Photons Plus Ultrasound: Imaging and Sensing 2018. Proceedings of SPIE. No.10494. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 104942X. ISBN 9781510614734.

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We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT) system to detect tumors and reveal detailed angiographic information about human breasts. SBH-PACT provides high spatial and temporal resolutions with a deep in vivo penetration depth of over 4 cm. A volumetric breast image can be acquired by scanning the breast within a single breath hold (~15 sec). We imaged a healthy female volunteer and seven breast cancer patients. SBH-PACT clearly identified all tumors by revealing higher blood vessel densities and lower compliance associated with the tumors.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
Lin, Li0000-0002-0517-8436
Hu, Peng0000-0002-2933-1239
Shi, Junhui0000-0002-5741-2781
Maslov, Konstantin0000-0003-3408-8840
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2018 Society of Photo-Optical Instrumentation Engineers. The authors would like to thank Xi Li and Ruth Holdener for useful discussions and patient recruitment. We are grateful to James Linders for technical support. We also thank Prof. James Ballard and Amy Leong for close reading of the paper. This work was sponsored by the United States National Institutes of Health (NIH) grants DP1 EB016986 (NIH Director’s Pioneer Award), R01 CA186567 (NIH Director’s Transformative Research Award), and R01 EB016963.
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 CA186567
NIHR01 EB016963
Subject Keywords:Single breath hold, breast imaging, photoacoustic computed tomography, elastography, angiogenesis
Series Name:Proceedings of SPIE
Issue or Number:10494
Record Number:CaltechAUTHORS:20180905-144425867
Persistent URL:
Official Citation:Li Lin, Li Lin, Peng Hu, Peng Hu, Junhui Shi, Junhui Shi, Catherine M. Appleton, Catherine M. Appleton, Konstantin Maslov, Konstantin Maslov, Lihong V. Wang, Lihong V. Wang, } "Clinical photoacoustic computed tomography of the human breast in vivo within a single breath hold", Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104942X (22 March 2018); doi: 10.1117/12.2290987;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89401
Deposited By: Tony Diaz
Deposited On:06 Sep 2018 16:43
Last Modified:16 Nov 2021 00:35

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