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Linear-array based full-view high-resolution photoacoustic computed tomography of whole mouse brain functions in vivo

Li, Lei and Zhang, Pengfei and Wang, Lihong V. (2018) Linear-array based full-view high-resolution photoacoustic computed tomography of whole mouse brain functions in vivo. In: Photons Plus Ultrasound: Imaging and Sensing 2018. Proceedings of SPIE. No.10494. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 104941H. ISBN 9781510614734. http://resolver.caltech.edu/CaltechAUTHORS:20180905-160453358

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Abstract

Photoacoustic computed tomography (PACT) is a non-invasive imaging technique offering high contrast, high resolution, and deep penetration in biological tissues. We report a photoacoustic computed tomography (PACT) system equipped with a high frequency linear array for anatomical and functional imaging of the mouse whole brain. The linear array was rotationally scanned in the coronal plane to achieve the full-view coverage. We investigated spontaneous neural activities in the deep brain by monitoring the hemodynamics and observed strong interhemispherical correlations between contralateral regions, both in the cortical layer and in the deep regions.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.2289118DOIArticle
ORCID:
AuthorORCID
Zhang, Pengfei0000-0002-4226-1394
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2018 Society of Photo-Optical Instrumentation Engineers. This work was funded by the National Institutes of Health (NIH) Grants U01 NS090579 (NIH Brain Initiative Award), U01 NS099717 (NIH Brain Initiative Award), R01 EB016963, DP1 EB016986 (Director’s Pioneer Award), R01 CA186567 (Director’s Transformative Research Award), S10 RR026922. The authors thank Prof. James Ballard for his close reading of the manuscript. L.V. Wang has a financial interest in Microphotoacoustics, Inc., CalPACT, LLC, and Union Photoacoustic Technologies, Ltd., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHU01 NS090579
NIHU01 NS099717
NIHR01 EB016963
NIHDP1 EB016986
NIHR01 CA186567
NIHS10 RR026922
Subject Keywords:Photoacoustic computed tomography; deep brain imaging; functional imaging
Record Number:CaltechAUTHORS:20180905-160453358
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180905-160453358
Official Citation:Lei Li, Lei Li, Pengfei Zhang, Pengfei Zhang, Lihong V. Wang, Lihong V. Wang, } "Linear-array based full-view high-resolution photoacoustic computed tomography of whole mouse brain functions in vivo", Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104941H (19 February 2018); doi: 10.1117/12.2289118; https://doi.org/10.1117/12.2289118
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89405
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 Sep 2018 16:39
Last Modified:06 Sep 2018 16:39

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