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Imaging dichroism by photoacoustic computed tomography

Li, Lei and Shen, Yuecheng and Yao, Junjie and Wong, Terence T. W. and Wang, Lihong V. and Qu, Yuan (2018) Imaging dichroism by photoacoustic computed tomography. In: Photons Plus Ultrasound: Imaging and Sensing 2018. Proceedings of SPIE. No.10494. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 104941U. ISBN 9781510614734.

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Conventional photoacoustic computed tomography (PACT) images the spatial distribution of optical absorption, which is approximated as an isotropic optical property. The optical absorption of many biological tissues, however, is anisotropic. This anisotropy, known as dichroism or diattenuation, encodes rich information about molecular conformation and structural alignment. Here we report a novel imaging method called dichroism-sensitive PACT (DS-PACT). Using a lock-detection strategy, our method can measure the amplitude of tissue’s dichroism and the orientation of the optic axis of uniaxial dichroic tissue, even at a depth of 3.25 transport mean free paths. We experimentally demonstrated DS-PACT by imaging plastic polarizers and ex vivo bovine tendons deep inside scattering media. Our method extends the functionality of PACT to include a new capability, imaging tissue absorption anisotropy.

Item Type:Book Section
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URLURL TypeDescription
Li, Lei0000-0001-6164-2646
Shen, Yuecheng0000-0003-1990-8142
Wong, Terence T. W.0000-0001-6399-758X
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2018 Society of Photo-Optical Instrumentation Engineers.
Series Name:Proceedings of SPIE
Issue or Number:10494
Record Number:CaltechAUTHORS:20180907-104552807
Persistent URL:
Official Citation:Yuan Qu, Yuan Qu, Lei Li, Lei Li, Yuecheng Shen, Yuecheng Shen, Junjie Yao, Junjie Yao, Terence T. W. Wong, Terence T. W. Wong, Lihong V. Wang, Lihong V. Wang, } "Imaging dichroism by photoacoustic computed tomography (Conference Presentation)", Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104941U (15 March 2018); doi: 10.1117/12.2287432;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89449
Deposited By: Tony Diaz
Deposited On:10 Sep 2018 19:49
Last Modified:09 Mar 2020 13:19

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