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In vivo rat deep brain imaging using photoacoustic computed tomography

Lin, Li and Li, Lei and Zhu, Liren and Hu, Peng and Wang, Lihong V. (2017) In vivo rat deep brain imaging using photoacoustic computed tomography. In: Photons Plus Ultrasound: Imaging and Sensing 2017. Proceedings of SPIE. No.10064. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 1006406. ISBN 9781510605695. https://resolver.caltech.edu/CaltechAUTHORS:20180907-104553675

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Abstract

The brain has been likened to a great stretch of unknown territory consisting of a number of unexplored continents. Small animal brain imaging plays an important role charting that territory. By using 1064 nm illumination from the side, we imaged the full coronal depth of rat brains in vivo. The experiment was performed using a real-time full-ring-array photoacoustic computed tomography (PACT) imaging system, which achieved an imaging depth of 11 mm and a 100 μm radial resolution. Because of the fast imaging speed of the full-ring-array PACT system, no animal motion artifact was induced. The frame rate of the system was limited by the laser repetition rate (50 Hz). In addition to anatomical imaging of the blood vessels in the brain, we continuously monitored correlations between the two brain hemispheres in one of the coronal planes. The resting states in the coronal plane were measured before and after stroke ligation surgery at a neck artery.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.2251213DOIArticle
ORCID:
AuthorORCID
Hu, Peng0000-0002-2933-1239
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2017 Society of Photo-Optical Instrumentation Engineers.
Series Name:Proceedings of SPIE
Issue or Number:10064
Record Number:CaltechAUTHORS:20180907-104553675
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180907-104553675
Official Citation:Li Lin, Li Lin, Lei Li, Lei Li, Liren Zhu, Liren Zhu, Peng Hu, Peng Hu, Lihong V. Wang, Lihong V. Wang, } "In vivo rat deep brain imaging using photoacoustic computed tomography (Conference Presentation)", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 1006406 (24 April 2017); doi: 10.1117/12.2251213; https://doi.org/10.1117/12.2251213
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89458
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:10 Sep 2018 18:02
Last Modified:03 Oct 2019 20:16

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