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In vivo microwave-based thermoacoustic tomography of rats

Lin, Li and Zhou, Yong and Wang, Lihong V. (2016) In vivo microwave-based thermoacoustic tomography of rats. In: Photons Plus Ultrasound: Imaging and Sensing 2016. Proceedings of SPIE. No.9708. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 97080U. ISBN 9781628419429.

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Microwave-based thermoacoustic tomography (TAT), based on the measurement of ultrasonic waves induced by microwave pulses, can reveal tissue dielectric properties that may be closely related to the physiological and pathological status of the tissues. Using microwaves as the excitation source improved imaging depth because of their deep penetration into biological tissues. We demonstrate, for the first time, in vivo microwave-based thermoacoustic imaging in rats. The transducer is rotated around the rat in a full circle, providing a full two-dimensional view. Instead of a flat ultrasonic transducer, we used a virtual line detector based on a cylindrically focused transducer. A 3 GHz microwave source with 0.6 µs pulse width and an electromagnetically shielded transducer with 2.25 MHz central frequency provided clear cross-sectional images of the rat’s body. The high imaging contrast, based on the tissue’s rate of absorption, and the ultrasonically defined spatial resolution combine to reveal the spine, kidney, muscle, and other deeply seated anatomical features in the rat’s abdominal cavity. This non-invasive and non-ionizing imaging modality achieved an imaging depth beyond 6 cm in the rat’s tissue. Cancer diagnosis based on information about tissue properties from microwave band TAT can potentially be more accurate than has previously been achievable.

Item Type:Book Section
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Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2016 Society of Photo-Optical Instrumentation Engineers.
Series Name:Proceedings of SPIE
Issue or Number:9708
Record Number:CaltechAUTHORS:20180907-104554377
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Official Citation:Li Lin, Li Lin, Yong Zhou, Yong Zhou, Lihong V. Wang, Lihong V. Wang, } "In vivo microwave-based thermoacoustic tomography of rats (Conference Presentation)", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97080U (27 April 2016); doi: 10.1117/12.2211053;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89466
Deposited By: Tony Diaz
Deposited On:08 Sep 2018 03:28
Last Modified:03 Oct 2019 20:16

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