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Image reconstruction in transcranial photoacoustic computed tomography of the brain

Mitsuhashi, Kenji and Wang, Lihong V. and Anastasio, Mark A. (2015) Image reconstruction in transcranial photoacoustic computed tomography of the brain. In: Photons Plus Ultrasound: Imaging and Sensing 2015. Proceedings of SPIE. No.9323. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 93233B. ISBN 9781628414134.

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Photoacoustic computed tomography (PACT) holds great promise for transcranial brain imaging. However, the strong reflection, scattering, attenuation, and mode-conversion of photoacoustic waves in the skull pose serious challenges to establishing the method. The lack of an appropriate model of solid media in conventional PACT imaging models, which are based on the canonical scalar wave equation, causes a significant model mismatch in the presence of the skull and thus results in deteriorated reconstructed images. The goal of this study was to develop an image reconstruction algorithm that accurately models the skull and thereby ameliorates the quality of reconstructed images. The propagation of photoacoustic waves through the skull was modeled by a viscoelastic stress tensor wave equation, which was subsequently discretized by use of a staggered grid fourth-order finite-difference time-domain (FDTD) method. The matched adjoint of the FDTD-based wave propagation operator was derived for implementing a back-projection operator. Systematic computer simulations were conducted to demonstrate the effectiveness of the back-projection operator for reconstructing images in a realistic three-dimensional PACT brain imaging system. The results suggest that the proposed algorithm can successfully reconstruct images from transcranially-measured pressure data and readily be translated to clinical PACT brain imaging applications.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
Wang, Lihong V.0000-0001-9783-4383
Anastasio, Mark A.0000-0002-3192-4172
Additional Information:© 2015 Society of Photo-Optical Instrumentation Engineers. This work was supported in part by NIH awards CA167446 and EB01696301.
Funding AgencyGrant Number
Subject Keywords:Photoacoustic computed tomography, Image reconstruction, Brain imaging
Series Name:Proceedings of SPIE
Issue or Number:9323
Record Number:CaltechAUTHORS:20180911-102322999
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Official Citation:Kenji Mitsuhashi, Kenji Mitsuhashi, Lihong V. Wang, Lihong V. Wang, Mark A. Anastasio, Mark A. Anastasio, } "Image reconstruction in transcranial photoacoustic computed tomography of the brain", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93233B (11 March 2015); doi: 10.1117/12.2081050;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89520
Deposited By: Tony Diaz
Deposited On:11 Sep 2018 20:02
Last Modified:03 Oct 2019 20:17

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