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In vivo photoacoustic flowmetry in the optical diffusive regime based on saline injection

Zhou, Yong and Poudel, Joemini and Li, Guo and Wang, Lihong V. (2016) In vivo photoacoustic flowmetry in the optical diffusive regime based on saline injection. In: Photons Plus Ultrasound: Imaging and Sensing 2016. Proceedings of SPIE. No.9708. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 97084U. ISBN 9781628419429.

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We propose a saline-injection-based method to quantify blood flow velocity in vivo with acoustic-resolution photoacoustic tomography. By monitoring the saline-blood-interface propagating in the blood vessel, we can resolve the flow velocity. In phantom experiments, a root-mean-squared error of prediction of 0.29 mm/s was achieved. By injecting saline into a mouse tail vein covered with 1 mm chicken tissue, we showed that the flow velocity in the tail vein could be measured at depth, which is especially pertinent to monitoring blood flow velocity in patients undergoing intravenous infusion.

Item Type:Book Section
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Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2016 Society of Photo-Optical Instrumentation Engineers. The authors would like to thank Prof. James Ballard for manuscript editing. This work was sponsored in part by National Institutes of Health grants DP1 EB016986 (NIH Director’s Pioneer Award), R01 CA186567 (NIH Director’s Transformative Research Award), R01 EB016963, S10 RR026922, and R01 CA159959. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 CA186567
NIHR01 EB016963
NIHS10 RR026922
NIHR01 CA159959
Subject Keywords:saline injection, blood flow velocity, acoustic-resolution photoacoustic tomography, intravenous infusion
Series Name:Proceedings of SPIE
Issue or Number:9708
Record Number:CaltechAUTHORS:20180911-140234611
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Official Citation:Yong Zhou, Yong Zhou, Joemini Poudel, Joemini Poudel, Guo Li, Guo Li, Lihong V. Wang, Lihong V. Wang, } "In vivo photoacoustic flowmetry in the optical diffusive regime based on saline injection", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97084U (15 March 2016); doi: 10.1117/12.2217468;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89526
Deposited By: Tony Diaz
Deposited On:11 Sep 2018 23:23
Last Modified:03 Oct 2019 20:17

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