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Mitigation of artifacts due to isolated acoustic heterogeneities in photoacoustic computed tomography using a variable data truncation-based reconstruction method

Poudel, Joemini and Matthews, Thomas P. and Li, Lei and Anastasio, Mark A. and Wang, Lihong V. (2017) Mitigation of artifacts due to isolated acoustic heterogeneities in photoacoustic computed tomography using a variable data truncation-based reconstruction method. Journal of Biomedical Optics, 22 (4). Art. No. 041018. ISSN 1083-3668. PMCID PMC5340213. https://resolver.caltech.edu/CaltechAUTHORS:20180911-144144268

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Abstract

Photoacoustic computed tomography (PACT) is an emerging computed imaging modality that exploits optical contrast and ultrasonic detection principles to form images of the absorbed optical energy density within tissue. If the object possesses spatially variant acoustic properties that are unaccounted for by the reconstruction method, the estimated image can contain distortions. While reconstruction methods have recently been developed to compensate for this effect, they generally require the object’s acoustic properties to be known a priori. To circumvent the need for detailed information regarding an object’s acoustic properties, we previously proposed a half-time reconstruction method for PACT. A half-time reconstruction method estimates the PACT image from a data set that has been temporally truncated to exclude the data components that have been strongly aberrated. However, this method can be improved upon when the approximate sizes and locations of isolated heterogeneous structures, such as bones or gas pockets, are known. To address this, we investigate PACT reconstruction methods that are based on a variable data truncation (VDT) approach. The VDT approach represents a generalization of the half-time approach, in which the degree of temporal truncation for each measurement is determined by the distance between the corresponding ultrasonic transducer location and the nearest known bone or gas void location. Computer-simulated and experimental data are employed to demonstrate the effectiveness of the approach in mitigating artifacts due to acoustic heterogeneities.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/1.JBO.22.4.041018DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340213/PubMed CentralArticle
ORCID:
AuthorORCID
Anastasio, Mark A.0000-0002-3192-4172
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2017 Society of Photo-Optical Instrumentation Engineers. Paper 160595SSR received Aug. 29, 2016; accepted for publication Feb. 17, 2017; published online Mar. 7, 2017. This work was supported in part by National Institutes of Health award Nos. CA1744601, EB01696301, and 5T32EB01485505. Disclosures: L. V. W. has a financial interest in Microphotoacoustics, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHCA1744601
NIHEB01696301
NIH Predoctoral Fellowship5T32EB01485505
Subject Keywords:image reconstruction; photoacoustic computed tomography
Issue or Number:4
PubMed Central ID:PMC5340213
Record Number:CaltechAUTHORS:20180911-144144268
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180911-144144268
Official Citation:Joemini Poudel, Joemini Poudel, Thomas P. Matthews, Thomas P. Matthews, Lei Li, Lei Li, Mark A. Anastasio, Mark A. Anastasio, Lihong V. Wang, Lihong V. Wang, } "Mitigation of artifacts due to isolated acoustic heterogeneities in photoacoustic computed tomography using a variable data truncation-based reconstruction method," Journal of Biomedical Optics 22(4), 041018 (7 March 2017). https://doi.org/10.1117/1.JBO.22.4.041018
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89530
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:11 Sep 2018 23:18
Last Modified:03 Oct 2019 20:17

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