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Investigation of effective system designs for transcranial photoacoustic tomography of the brain

Mitsuhashi, Kenji and Schoonover, Robert W. and Huang, Chao and Wang, Lihong V. and Anastasio, Mark A. (2014) Investigation of effective system designs for transcranial photoacoustic tomography of the brain. In: Photons Plus Ultrasound: Imaging and Sensing 2014. Proceedings of SPIE. No.8943. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 894369. ISBN 9780819498564.

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Photoacoustic computed tomography (PACT) holds great promise for transcranial brain imaging. However, the strong reflection, scattering and attenuation of acoustic waves in the skull present significant challenges to developing this method. We report on a systematic computer-simulation study of transcranial brain imaging using PACT. The goal of this study was to identify an effective imaging system design that can be translated for clinical use. The propagation of photoacoustic waves through a model skull was studied by use of an elastic finite-difference time-domain (FDTD) method. The acoustic radiation pattern from a photoacoustic source just beneath the skull was observed with a ring transducer array that was level with the source. The observed radiation pattern was found to contain stronger contributions from waves that were converted to shear waves in skull than longitudinal waves that did not undergo mode conversion. Images reconstructed from the pressure data that contain shear wave components possess better resolution than images reconstructed from the data that only contain the longitudinal wave signals. These observations revealed that the detection system should be designed to capture photoacoustic signals that travel through the skull in the form of shear waves as well as in the form of longitudinal waves. A preliminary investigation on the effect of the presence of absorption in the skull is also reported. This study provides an insight into the wave phenomena in transcranial PACT imaging, as well as a concrete detection design strategy that mitigates the degraded resolution of reconstructed images.

Item Type:Book Section
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URLURL TypeDescription
Wang, Lihong V.0000-0001-9783-4383
Anastasio, Mark A.0000-0002-3192-4172
Additional Information:© 2014 Society of Photo-Optical Instrumentation Engineers. This work was supported in part by NIH awards EB010049 and EB014617 (F32).
Funding AgencyGrant Number
Subject Keywords:Photoacoustic computed tomography, Image reconstruction, Brain imaging
Series Name:Proceedings of SPIE
Issue or Number:8943
Record Number:CaltechAUTHORS:20180911-161800611
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Official Citation:Kenji Mitsuhashi, Kenji Mitsuhashi, Robert W. Schoonover, Robert W. Schoonover, Chao Huang, Chao Huang, Lihong V. Wang, Lihong V. Wang, Mark A. Anastasio, Mark A. Anastasio, } "Investigation of effective system designs for transcranial photoacoustic tomography of the brain", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 894369 (3 March 2014); doi: 10.1117/12.2041998;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89534
Deposited By: Tony Diaz
Deposited On:11 Sep 2018 23:27
Last Modified:03 Oct 2019 20:17

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