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Functional connectivity in the mouse brain imaged by B-mode photoacoustic microscopy

Nasiriavanaki, Mohammadreza and Xing, Wenxin and Xia, Jun and Wang, Lihong V. (2014) Functional connectivity in the mouse brain imaged by B-mode photoacoustic microscopy. In: Photons Plus Ultrasound: Imaging and Sensing 2014. Proceedings of SPIE. No.8943. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 894364. ISBN 9780819498564. https://resolver.caltech.edu/CaltechAUTHORS:20180912-073236986

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Abstract

The increasing use of mouse models for human brain disease studies, coupled with the fact that existing functional imaging modalities cannot be easily applied to mice, presents an emerging need for a new functional imaging modality. Utilizing acoustic-resolution photoacoustic microscopy (AR-PAM), we imaged spontaneous cerebral hemodynamic fluctuations and their associated functional connections in the mouse brain. The images were acquired noninvasively in B-scan mode with a fast frame rate, a large field of view, and a high spatial resolution. At a location relative to the bregma 0, correlations were investigated inter-hemispherically between bilaterally homologous regions, as well as intra-hemispherically within the same functional regions. The functional connectivity in different functional regions was studied. The locations of these regions agreed well with the Paxinos mouse brain atlas. The functional connectivity map obtained in this study can then be used in the investigation of brain disorders such as stroke, Alzheimer’s, schizophrenia, multiple sclerosis, autism, and epilepsy. Our experiments show that photoacoustic microscopy is capable to detect connectivities between different functional regions in B-scan mode, promising a powerful functional imaging modality for future brain research.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.2036638DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2014 Society of Photo-Optical Instrumentation Engineers. The authors acknowledge and thank Prof. James Ballard, for his close look at the manuscript. This work was sponsored in part by National Institutes of Health grants R01 EB000712, R01 EB008085, R01 CA134539, R01 CA159959, U54 CA136398, R01 EB010049, and DP1 EB016986 (NIH Director’s Pioneer Award). L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 EB008085
NIHR01 CA134539
NIHR01 CA159959
NIHU54 CA136398
NIHR01 EB010049
NIHDP1 EB016986
Subject Keywords:B-scan mode, Resting-state functional connectivity, Functional imaging, Acoustic-resolution photoacoustic microscopy
Series Name:Proceedings of SPIE
Issue or Number:8943
Record Number:CaltechAUTHORS:20180912-073236986
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180912-073236986
Official Citation:Mohammadreza Nasiriavanaki, Mohammadreza Nasiriavanaki, Wenxin Xing, Wenxin Xing, Jun Xia, Jun Xia, Lihong V. Wang, Lihong V. Wang, } "Functional connectivity in the mouse brain imaged by B-mode photoacoustic microscopy", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 894364 (3 March 2014); doi: 10.1117/12.2036638; https://doi.org/10.1117/12.2036638
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89551
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Sep 2018 19:05
Last Modified:03 Oct 2019 20:17

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