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Localized fluorescence excitation in opaque media by time-reversed ultrasonically encoded (TRUE) optical focusing

Suzuki, Yuta and Lai, Puxiang and Xu, Xiao and Wang, Lihong (2014) Localized fluorescence excitation in opaque media by time-reversed ultrasonically encoded (TRUE) optical focusing. In: Photons Plus Ultrasound: Imaging and Sensing 2014. Proceedings of SPIE. No.8943. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 894358. ISBN 9780819498564. https://resolver.caltech.edu/CaltechAUTHORS:20180912-091734762

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Abstract

To focus light beyond one transport mean free path, time-reversed ultrasonically encoded (TRUE) optical focusing has previously been implemented by both analog and digital devices. By allowing wavefront recording with finer resolution and larger aperture, the analog scheme, which uses photorefractive materials as the phase-conjugate mirror, generates a more complete set of time-reversed optical modes than the digital scheme. Here, we report the direct visualization of localized fluorescence excitation inside a turbid medium by photorefractive time reversal. Further, we imaged fluorescent targets embedded in a turbid phantom whose thickness was four transport mean free paths.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.2037947DOIArticle
ORCID:
AuthorORCID
Wang, Lihong0000-0001-9783-4383
Additional Information:© 2014 Society of Photo-Optical Instrumentation Engineers. We would like to thank Nitto Denko Technical (Oceanside, CA, USA) for providing the photorefractive polymer for this research. This work was sponsored in part by the National Academies Keck Futures Initiative grant IS 13 and National Institute of Health grants DPI EB016986 (NIH Director’s Pioneer Award), R01 EB000712 and U54 CA136398.
Funders:
Funding AgencyGrant Number
National Academies Keck Futures InitiativeIS 13
NIHDP1 EB016986
NIHR01 EB000712
NIHU54 CA136398
Subject Keywords:optical focusing, ultrasound modulation, optical imaging, phase conjugation, time reversal, photorefractive material
Series Name:Proceedings of SPIE
Issue or Number:8943
Record Number:CaltechAUTHORS:20180912-091734762
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180912-091734762
Official Citation:Yuta Suzuki, Yuta Suzuki, Puxiang Lai, Puxiang Lai, Xiao Xu, Xiao Xu, Lihong Wang, Lihong Wang, } "Localized fluorescence excitation in opaque media by time-reversed ultrasonically encoded (TRUE) optical focusing", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 894358 (3 March 2014); doi: 10.1117/12.2037947; https://doi.org/10.1117/12.2037947
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89555
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Sep 2018 19:02
Last Modified:03 Oct 2019 20:17

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