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High-speed time-reversed ultrasonically encoded (TRUE) optical focusing inside dynamic scattering media at 793 nm

Liu, Yan and Lai, Puxiang and Ma, Cheng and Xu, Xiao and Suzuki, Yuta and Grabar, Alexander A. and Wang, Lihong V. (2014) High-speed time-reversed ultrasonically encoded (TRUE) optical focusing inside dynamic scattering media at 793 nm. In: Photons Plus Ultrasound: Imaging and Sensing 2014. Proceedings of SPIE. No.8943. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 894339. ISBN 9780819498564.

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Time-reversed ultrasonically encoded (TRUE) optical focusing is an emerging technique that focuses light deep into scattering media by phase-conjugating ultrasonically encoded diffuse light. In previous work, the speed of TRUE focusing was limited to no faster than 1 Hz by the response time of the photorefractive phase conjugate mirror, or the data acquisition and streaming speed of the digital camera; photorefractive-crystal-based TRUE focusing was also limited to the visible spectral range. These time-consuming schemes prevent this technique from being applied in vivo, since living biological tissue has a speckle decorrelation time on the order of a millisecond. In this work, using a Tedoped Sn_2P_2S_6 photorefractive crystal at a near-infrared wavelength of 793 nm, we achieved TRUE focusing inside dynamic scattering media having a speckle decorrelation time as short as 7.7 ms. As the achieved speed approaches the tissue decorrelation rate, this work is an important step forward toward in vivo applications of TRUE focusing in deep tissue imaging, photodynamic therapy, and optical manipulation.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
Liu, Yan0000-0002-5837-4908
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2014 Society of Photo-Optical Instrumentation Engineers. This work was sponsored in part by National Institute of Health grants DP1 EB016986 (NIH Director’s Pioneer Award) and R01 CA186567 (NIH Director’s Transformative Research Award) as well as National Academies Keck Futures Initiative grant IS 13. L. W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 CA186567
National Academies Keck Futures InitiativeIS 13
Subject Keywords:Time-Reversed Ultrasonically Encoded (TRUE) optical focusing, optical phase conjugation, optical time reversal, light scattering, turbid media, optical focusing
Series Name:Proceedings of SPIE
Issue or Number:8943
Record Number:CaltechAUTHORS:20180912-093051932
Persistent URL:
Official Citation:Yan Liu, Yan Liu, Puxiang Lai, Puxiang Lai, Cheng Ma, Cheng Ma, Xiao Xu, Xiao Xu, Yuta Suzuki, Yuta Suzuki, Alexander A. Grabar, Alexander A. Grabar, Lihong V. Wang, Lihong V. Wang, } "High-speed time-reversed ultrasonically encoded (TRUE) optical focusing inside dynamic scattering media at 793 nm", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 894339 (3 March 2014); doi: 10.1117/12.2039815;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89559
Deposited By: Tony Diaz
Deposited On:12 Sep 2018 19:00
Last Modified:16 Nov 2021 00:36

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