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Co-registered spectral photoacoustic tomography and ultrasonography of breast cancer

Ke, Haixin and Erpelding, Todd N. and Garcia-Uribe, Alejandro and Jacobs, Eileen and Holley, Susan and Monsees, Barbara and Wang, Lihong V. (2014) Co-registered spectral photoacoustic tomography and ultrasonography of breast cancer. In: Photons Plus Ultrasound: Imaging and Sensing 2014. Proceedings of SPIE. No.8943. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 89434G. ISBN 9780819498564. http://resolver.caltech.edu/CaltechAUTHORS:20180912-101331425

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Abstract

Many breast cancer patients receive neoadjuvant treatment to reduce tumor size and enable breast conserving therapy. Most imaging methods used to monitor response to neoadjuvant chemotherapy or hormone therapy depend on overall gross tumor morphology and size measurements, which may not be sensitive or specific, despite tumor response on a cellular level. A more sensitive and specific method of detecting response to therapy might allow earlier adjustments in treatment, and thus result in better outcomes while avoiding unnecessary morbidity. We developed an imaging system that combines spectral photoacoustic tomography and ultrasonography to predict breast neoadjuvant therapeutic response based on blood volume and blood oxygenation contrast. The system consists of a tunable dye laser pumped by a Nd:YAG laser, a commercial ultrasound imaging system (Philips iU22), and a multichannel data acquisition system which displays co-registered photoacoustic and ultrasound images in real time. Early studies demonstrate functional imaging capabilities, such as oxygen saturation and total concentration of hemoglobin, in addition to ultrasonography of tumor morphology. Further study is needed to determine if the co-registered photoacoustic tomography and ultrasonography system may provide an accurate tool to assess treatment efficacy by monitoring tumor response in vivo.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.2040591DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2014 Society of Photo-Optical Instrumentation Engineers. This work was sponsored by NIH grants R01 CA134539, DP1 EB016986 (NIH Director’s Pioneer Award), R01 EB016963, and U54 CA136398. L. V. Wang has a financial interest in Endra, Inc., and Microphotoacoustics, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHR01 CA134539
NIHDP1 EB016986
NIHR01 EB016963
NIHU54 CA136398
Subject Keywords:Neoadjuvant chemotherapy, photoacoustic tomography, ultrasonography, breast cancer
Record Number:CaltechAUTHORS:20180912-101331425
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180912-101331425
Official Citation:Haixin Ke, Haixin Ke, Todd N. Erpelding, Todd N. Erpelding, Alejandro Garcia-Uribe, Alejandro Garcia-Uribe, Eileen Jacobs, Eileen Jacobs, Susan Holley, Susan Holley, Barbara Monsees, Barbara Monsees, Lihong V. Wang, Lihong V. Wang, } "Co-registered spectral photoacoustic tomography and ultrasonography of breast cancer", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 89434G (3 March 2014); doi: 10.1117/12.2040591; https://doi.org/10.1117/12.2040591
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89568
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Sep 2018 18:44
Last Modified:12 Sep 2018 18:44

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