Ke, Haixin and Erpelding, Todd N. and Garcia-Uribe, Alejandro and Jacobs, Eileen and Holley, Susan and Monsees, Barbara and Wang, Lihong V. (2014) Co-registered spectral photoacoustic tomography and ultrasonography of breast cancer. In: Photons Plus Ultrasound: Imaging and Sensing 2014. Proceedings of SPIE. No.8943. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 89434G. ISBN 9780819498564. https://resolver.caltech.edu/CaltechAUTHORS:20180912-101331425
![]() |
PDF
- Published Version
See Usage Policy. 539Kb |
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20180912-101331425
Abstract
Many breast cancer patients receive neoadjuvant treatment to reduce tumor size and enable breast conserving therapy. Most imaging methods used to monitor response to neoadjuvant chemotherapy or hormone therapy depend on overall gross tumor morphology and size measurements, which may not be sensitive or specific, despite tumor response on a cellular level. A more sensitive and specific method of detecting response to therapy might allow earlier adjustments in treatment, and thus result in better outcomes while avoiding unnecessary morbidity. We developed an imaging system that combines spectral photoacoustic tomography and ultrasonography to predict breast neoadjuvant therapeutic response based on blood volume and blood oxygenation contrast. The system consists of a tunable dye laser pumped by a Nd:YAG laser, a commercial ultrasound imaging system (Philips iU22), and a multichannel data acquisition system which displays co-registered photoacoustic and ultrasound images in real time. Early studies demonstrate functional imaging capabilities, such as oxygen saturation and total concentration of hemoglobin, in addition to ultrasonography of tumor morphology. Further study is needed to determine if the co-registered photoacoustic tomography and ultrasonography system may provide an accurate tool to assess treatment efficacy by monitoring tumor response in vivo.
Item Type: | Book Section | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Related URLs: |
| ||||||||||
ORCID: |
| ||||||||||
Additional Information: | © 2014 Society of Photo-Optical Instrumentation Engineers. This work was sponsored by NIH grants R01 CA134539, DP1 EB016986 (NIH Director’s Pioneer Award), R01 EB016963, and U54 CA136398. L. V. Wang has a financial interest in Endra, Inc., and Microphotoacoustics, Inc., which, however, did not support this work. | ||||||||||
Funders: |
| ||||||||||
Subject Keywords: | Neoadjuvant chemotherapy, photoacoustic tomography, ultrasonography, breast cancer | ||||||||||
Series Name: | Proceedings of SPIE | ||||||||||
Issue or Number: | 8943 | ||||||||||
Record Number: | CaltechAUTHORS:20180912-101331425 | ||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180912-101331425 | ||||||||||
Official Citation: | Haixin Ke, Haixin Ke, Todd N. Erpelding, Todd N. Erpelding, Alejandro Garcia-Uribe, Alejandro Garcia-Uribe, Eileen Jacobs, Eileen Jacobs, Susan Holley, Susan Holley, Barbara Monsees, Barbara Monsees, Lihong V. Wang, Lihong V. Wang, } "Co-registered spectral photoacoustic tomography and ultrasonography of breast cancer", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 89434G (3 March 2014); doi: 10.1117/12.2040591; https://doi.org/10.1117/12.2040591 | ||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||
ID Code: | 89568 | ||||||||||
Collection: | CaltechAUTHORS | ||||||||||
Deposited By: | Tony Diaz | ||||||||||
Deposited On: | 12 Sep 2018 18:44 | ||||||||||
Last Modified: | 03 Oct 2019 20:17 |
Repository Staff Only: item control page