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Macrocyclic peptide construction through C-H activation strategy

Chen, Kai and Shi, Bing-Feng (2018) Macrocyclic peptide construction through C-H activation strategy. Science Bulletin, 63 (19). pp. 1238-1240. ISSN 2095-9273.

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Peptides are biomolecules that commonly engage in biological activities of native bio-systems, and have also been inspiringly investigated, synthesized and utilized by human beings for clinical purposes. The function of a peptide is typically dependent on its amino acid sequence and three-dimensional structure. Among all types of peptides, macrocyclic ones that confer well-defined conformations and extended surface, and thus lead to enhanced thermo/metabolic stability and cell permeability, have emerged as highly promising candidates in therapeutic development, as exemplified by Vancomycin antibiotics [1]. To construct such peptidic macrocycles, nature has demonstrated privileged machineries by employing a set of different enzymes to assemble all fragments. However, such biosynthetic scenarios are very limited to those natively found products and difficult to be extended to designed macrocyclic peptides, which prompts chemists to develop synthetic methods to expand their structural diversity and also explore their potential biological applications.

Item Type:Article
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Chen, Kai0000-0002-3325-3536
Shi, Bing-Feng0000-0003-0375-955X
Additional Information:© 2018 Science China Press. Published by Elsevier B.V. and Science China Press. Available online 13 September 2018.
Record Number:CaltechAUTHORS:20180913-133340664
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Official Citation:Kai Chen, Bing-Feng Shi, Macrocyclic peptide construction through C–H activation strategy, Science Bulletin, Volume 63, Issue 19, 2018, Pages 1238-1240, ISSN 2095-9273, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89626
Deposited By: Tony Diaz
Deposited On:13 Sep 2018 20:49
Last Modified:28 Sep 2018 21:47

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