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Combined optical- and acoustic-resolution photoacoustic microscopy based on an optical fiber bundle

Xing, Wenxin and Wang, Lidai and Maslov, Konstantin and Wang, Lihong V. (2013) Combined optical- and acoustic-resolution photoacoustic microscopy based on an optical fiber bundle. In: Photons Plus Ultrasound: Imaging and Sensing 2013. Proceedings of SPIE. No.8581. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 858142. ISBN 9780819493507. https://resolver.caltech.edu/CaltechAUTHORS:20180914-150421560

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Abstract

Photoacoustic microscopy (PAM), whose spatial resolution and penetration depth are both scalable, has made great progress in recent years. According to their different lateral resolutions, PAM systems can be categorized into either optical-resolution (OR) PAM, with optical-diffraction-limited lateral resolution, or acoustic-resolution (AR) PAM, with acoustically limited resolution and a deeper maximum imaging depth. In this report, we present a combined OR and AR PAM system with resolutions of 2.2 μm and 40 μm, respectively. Sharing most components between the OR and AR implementations, the system achieves separated illumination for OR and AR imaging by an optical fiber bundle through different channels, and two discrete lasers are used to provide either high-power energy for AR imaging or highrepetition- rate pulses for OR imaging. The design enables automatically co-registered OR and AR photoacoustic imaging in one single system, which extends the usability of current photoacoustic systems and simplifies the imaging procedure.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.2005259DOIArticle
ORCID:
AuthorORCID
Maslov, Konstantin0000-0003-3408-8840
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was sponsored by National Institutes of Health (NIH) grants R43 HL106855, R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 CA157277, R01 CA159959, as well as the Cancer Frontier Fund. L. V. Wang has a financial interest in Microphotoacoustics, Inc., and Endra, Inc., which did not support this work. K. Maslov has a financial interest in Microphotoacoustics, Inc. which did not support this work. The authors appreciate Prof. James Ballard’s close reading of the manuscript.
Funders:
Funding AgencyGrant Number
NIHR43 HL106855
NIHR01 EB000712
NIHR01 EB008085
NIHR01 CA134539
NIHU54 CA136398
NIHR01 CA157277
NIHR01 CA159959
Cancer Frontier FundUNSPECIFIED
Subject Keywords:Photoacoustic imaging, fiber bundle
Series Name:Proceedings of SPIE
Issue or Number:8581
DOI:10.1117/12.2005259
Record Number:CaltechAUTHORS:20180914-150421560
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180914-150421560
Official Citation:Wenxin Xing, Wenxin Xing, Lidai Wang, Lidai Wang, Konstantin Maslov, Konstantin Maslov, Lihong V. Wang, Lihong V. Wang, } "Combined optical- and acoustic-resolution photoacoustic microscopy based on an optical fiber bundle", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 858142 (4 March 2013); doi: 10.1117/12.2005259; https://doi.org/10.1117/12.2005259
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89658
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:14 Sep 2018 23:06
Last Modified:16 Nov 2021 00:37

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