A Caltech Library Service

Anatomical and metabolic small-animal whole-body imaging using ring-shaped confocal photoacoustic computed tomography

Xia, Jun and Chatni, Muhammad and Maslov, Konstantin and Wang, Lihong V. (2013) Anatomical and metabolic small-animal whole-body imaging using ring-shaped confocal photoacoustic computed tomography. In: Photons Plus Ultrasound: Imaging and Sensing 2013. Proceedings of SPIE. No.8581. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 85810K. ISBN 9780819493507.

[img] PDF - Published Version
See Usage Policy.


Use this Persistent URL to link to this item:


Due to the wide use of animals for human disease studies, small animal whole-body imaging plays an increasingly important role in biomedical research. Currently, none of the existing imaging modalities can provide both anatomical and glucose metabolic information, leading to higher costs of building dual-modality systems. Even with image coregistration, the spatial resolution of the metabolic imaging modality is not improved. We present a ring-shaped confocal photoacoustic computed tomography (RC-PACT) system that can provide both assessments in a single modality. Utilizing the novel design of confocal full-ring light delivery and ultrasound transducer array detection, RC-PACT provides full-view cross-sectional imaging with high spatial resolution. Scanning along the orthogonal direction provides three-dimensional imaging. While the mouse anatomy was imaged with endogenous hemoglobin contrast, the glucose metabolism was imaged with a near-infrared dye-labeled 2-deoxyglucose. Through mouse tumor models, we demonstrate that RC-PACT may be a paradigm shifting imaging method for preclinical research.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
Maslov, Konstantin0000-0003-3408-8840
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE). The authors appreciate Ms. Seema Dahlheimer’s close reading of the manuscript. This work was sponsored in part by National Institutes of Health grants R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 EB010049, R01 CA157277, R01 CA159959, and 5P60 DK02057933. L.W. has financial interests in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 EB008085
NIHR01 CA134539
NIHU54 CA136398
NIHR01 EB010049
NIHR01 CA157277
NIHR01 CA159959
NIH5P60 DK02057933
Subject Keywords:Photoacoustic computed tomography, small-animal whole-body imaging, metabolic imaging
Series Name:Proceedings of SPIE
Issue or Number:8581
Record Number:CaltechAUTHORS:20180914-154406451
Persistent URL:
Official Citation:Jun Xia, Jun Xia, Muhammad Chatni, Muhammad Chatni, Konstantin Maslov, Konstantin Maslov, Lihong V. Wang, Lihong V. Wang, } "Anatomical and metabolic small-animal whole-body imaging using ring-shaped confocal photoacoustic computed tomography", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85810K (4 March 2013); doi: 10.1117/12.2004937;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89662
Deposited By: George Porter
Deposited On:14 Sep 2018 23:17
Last Modified:16 Nov 2021 00:37

Repository Staff Only: item control page