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Carbon nanoparticles as a multimodal thermoacoustic and photoacoustic contrast agent

Cai, Xin and Wu, Lina and Xing, Wenxin and Xia, Jun and Nie, Liming and Zhang, Ruiying and Lanza, Gregory M. and Shen, Baozhong and Pan, Dipanjan and Wang, Lihong V. (2013) Carbon nanoparticles as a multimodal thermoacoustic and photoacoustic contrast agent. In: Photons Plus Ultrasound: Imaging and Sensing 2013. Proceedings of SPIE. No.8581. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 858140. ISBN 9780819493507.

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We demonstrated the potential of carbon nanoparticles (CNPs) as exogenous contrast agents for both thermoacoustic (TA) tomography (TAT) and photoacoustic (PA) tomography (PAT). In comparison to deionized water, the CNPs provided a four times stronger signal in TAT at 3 GHz. In comparison to blood, The CNPs provided a much stronger signal in PAT over a broad wavelength range of 450-850 nm. Specifically, the maximum signal enhancement in PAT was 9.4 times stronger in the near-infrared window of 635-670 nm. In vivo blood-vessel PA imaging was performed non-invasively on a mouse femoral area. The images, captured after the tail vein injection of CNPs, show a gradual enhancement of the optical absorption in the vessels by up to 230%. The results indicate that CNPs can be potentially used as contrast agents for TAT and PAT to monitor the intravascular or extravascular pathways in clinical applications.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
Zhang, Ruiying0000-0002-0092-0814
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE). Our work was sponsored by NIH grants R01 EB000712, R01 EB008085, R01 CA140220, R01 CA157277, R01 CA159959, U54 CA136398, and DP1 EB016986—NIH Director’s Pioneer Award. L.V.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. Others claim no competing financial interests.
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 EB008085
NIHR01 CA140220
NIHR01 CA157277
NIHR01 CA159959
NIHU54 CA136398
NIHDP1 EB016986
Subject Keywords: Contrast agents; carbon; photoacoustic tomography; thermoacoutic tomography; nanoparticle
Series Name:Proceedings of SPIE
Issue or Number:8581
Record Number:CaltechAUTHORS:20180917-094549046
Persistent URL:
Official Citation:Xin Cai, Xin Cai, Lina Wu, Lina Wu, Wenxin Xing, Wenxin Xing, Jun Xia, Jun Xia, Liming Nie, Liming Nie, Ruiying Zhang, Ruiying Zhang, Gregory M. Lanza, Gregory M. Lanza, Baozhong Shen, Baozhong Shen, Dipanjan Pan, Dipanjan Pan, Lihong V. Wang, Lihong V. Wang, } "Carbon nanoparticles as a multimodal thermoacoustic and photoacoustic contrast agent", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 858140 (4 March 2013); doi: 10.1117/12.2005064;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89668
Deposited By: George Porter
Deposited On:17 Sep 2018 19:30
Last Modified:16 Nov 2021 00:37

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