Yeh, Chenghung and Hu, Song and Maslov, Konstantin and Wang, Lihong V. (2013) Blood pulse wave velocity measured by photoacoustic microscopy. In: Photons Plus Ultrasound: Imaging and Sensing 2013. Proceedings of SPIE. No.8581. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 85812C. ISBN 9780819493507. https://resolver.caltech.edu/CaltechAUTHORS:20180917-094549168
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Abstract
Blood pulse wave velocity (PWV) is an important indicator for vascular stiffness. In this letter, we present electrocardiogram-synchronized photoacoustic microscopy for in vivo noninvasive quantification of the PWV in the peripheral vessels of mice. Interestingly, strong correlation between blood flow speed and ECG were clearly observed in arteries but not in veins. PWV is measured by the pulse travel time and the distance between two spot of a chose vessel, where simultaneously recorded electrocardiograms served as references. Statistical analysis shows a linear correlation between the PWV and the vessel diameter, which agrees with known physiology. Keywords: photoacoustic microscopy, photoacoustic spectroscopy, bilirubin, scattering medium.
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| Additional Information: | © 2013 Society of Photo-Optical Instrumentation Engineers (SPIE). The authors appreciate the close reading of the manuscript by Profs. James Ballard, Seema Dahlheimer, and Lynnea Brumbaugh. Thanks to Amy Winkler and Brian Soetikno for helpful discussions. Thanks to Di Lang for experimental assistance. This work was sponsored by National Institutes of Health Grants R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 CA157277, and R01 CA159959. L.V.W. has financial interests in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. K. Maslov has a financial interest in Microphotoacoustics, Inc. | ||||||||||||||
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| Subject Keywords: | photoacoustic microscopy, photoacoustic spectroscopy, bilirubin, scattering medium | ||||||||||||||
| Series Name: | Proceedings of SPIE | ||||||||||||||
| Issue or Number: | 8581 | ||||||||||||||
| DOI: | 10.1117/12.2004232 | ||||||||||||||
| Record Number: | CaltechAUTHORS:20180917-094549168 | ||||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180917-094549168 | ||||||||||||||
| Official Citation: | Chenghung Yeh, Chenghung Yeh, Song Hu, Song Hu, Konstantin Maslov, Konstantin Maslov, Lihong V. Wang, Lihong V. Wang, } "Blood pulse wave velocity measured by photoacoustic microscopy", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85812C (4 March 2013); doi: 10.1117/12.2004232; https://doi.org/10.1117/12.2004232 | ||||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||
| ID Code: | 89669 | ||||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||||
| Deposited By: | George Porter | ||||||||||||||
| Deposited On: | 17 Sep 2018 19:28 | ||||||||||||||
| Last Modified: | 16 Nov 2021 00:37 |
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