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Resting-state functional connectivity imaging of the mouse brain using photoacoustic tomography

Nasiriavanaki, Mohammadreza and Xia, Jun and Wan, Hanlin and Bauer, Adam Q. and Culver, Joseph P. and Wang, Lihong V. (2014) Resting-state functional connectivity imaging of the mouse brain using photoacoustic tomography. In: Photons Plus Ultrasound: Imaging and Sensing 2014. Proceedings of SPIE. No.8943. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 89432O. ISBN 9780819498564. https://resolver.caltech.edu/CaltechAUTHORS:20180917-151059756

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Abstract

Resting-state functional connectivity (RSFC) imaging is an emerging neuroimaging approach that aims to identify spontaneous cerebral hemodynamic fluctuations and their associated functional connections. Clinical studies have demonstrated that RSFC is altered in brain disorders such as stroke, Alzheimer’s, autism, and epilepsy. However, conventional neuroimaging modalities cannot easily be applied to mice, the most widely used model species for human brain disease studies. For instance, functional magnetic resonance imaging (fMRI) of mice requires a very high magnetic field to obtain a sufficient signal-to-noise ratio and spatial resolution. Functional connectivity mapping with optical intrinsic signal imaging (fcOIS) is an alternative method. Due to the diffusion of light in tissue, the spatial resolution of fcOIS is limited, and experiments have been performed using an exposed skull preparation. In this study, we show for the first time, the use of photoacoustic computed tomography (PACT) to noninvasively image resting-state functional connectivity in the mouse brain, with a large field of view and a high spatial resolution. Bilateral correlations were observed in eight regions, as well as several subregions. These findings agreed well with the Paxinos mouse brain atlas. This study showed that PACT is a promising, non-invasive modality for small-animal functional brain imaging.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.2036606DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE). The authors acknowledge and thank Prof. James Ballard, for his close look at the manuscript. This work was sponsored in part by National Institutes of Health grants R01 EB000712, R01 EB008085, R01 CA134539, R01 CA159959, U54 CA136398, R01 EB010049, and DP1 EB016986 (NIH Director’s Pioneer Award). L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 EB008085
NIHR01 CA134539
NIHR01 CA159959
NIHU54 CA136398
NIHR01 EB010049
NIHDP1 EB016986
Subject Keywords:Functional Imaging, Photoacoustic Tomography, Electrical Stimulation
Series Name:Proceedings of SPIE
Issue or Number:8943
Record Number:CaltechAUTHORS:20180917-151059756
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180917-151059756
Official Citation:Mohammadreza Nasiriavanaki, Mohammadreza Nasiriavanaki, Jun Xia, Jun Xia, Hanlin Wan, Hanlin Wan, Adam Q. Bauer, Adam Q. Bauer, Joseph P. Culver, Joseph P. Culver, Lihong V. Wang, Lihong V. Wang, } "Resting-state functional connectivity imaging of the mouse brain using photoacoustic tomography", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 89432O (3 March 2014); doi: 10.1117/12.2036606; https://doi.org/10.1117/12.2036606
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89690
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:17 Sep 2018 22:26
Last Modified:03 Oct 2019 20:18

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