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Crimping-induced structural gradients explain the lasting strength of poly L-lactide bioresorbable vascular scaffolds during hydrolysis

Ramachandran, Karthik and Di Luccio, Tiziana and Ailianou, Artemis and Kossuth, Mary Beth and Oberhauser, James P. and Kornfield, Julia A. (2018) Crimping-induced structural gradients explain the lasting strength of poly L-lactide bioresorbable vascular scaffolds during hydrolysis. Proceedings of the National Academy of Sciences of the United States of America, 115 (41). pp. 10239-10244. ISSN 0027-8424. PMCID PMC6187115. doi:10.1073/pnas.1807347115.

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Biodegradable polymers open the way to treatment of heart disease using transient implants (bioresorbable vascular scaffolds, BVSs) that overcome the most serious complication associated with permanent metal stents—late stent thrombosis. Here, we address the long-standing paradox that the clinically approved BVS maintains its radial strength even after 9 mo of hydrolysis, which induces a ∼40% decrease in the poly L-lactide molecular weight (Mn). X-ray microdiffraction evidence of nonuniform hydrolysis in the scaffold reveals that regions subjected to tensile stress during crimping develop a microstructure that provides strength and resists hydrolysis. These beneficial morphological changes occur where they are needed most—where stress is localized when a radial load is placed on the scaffold. We hypothesize that the observed decrease in Mn reflects the majority of the material, which is undeformed during crimping. Thus, the global measures of degradation may be decoupled from the localized, degradation-resistant regions that confer the ability to support the artery for the first several months after implantation.

Item Type:Article
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URLURL TypeDescription Information CentralArticle
Ramachandran, Karthik0000-0003-1820-7555
Di Luccio, Tiziana0000-0001-8947-0655
Kornfield, Julia A.0000-0001-6746-8634
Additional Information:© 2018 The Author(s). Published under the PNAS license. Edited by Frank S. Bates, University of Minnesota, Minneapolis, MN, and approved August 17, 2018 (received for review May 9, 2018). PNAS published ahead of print September 17, 2018 We thank Dr. Zhonghou Cai (Advanced Photon Source, APS) for his assistance in collecting X-ray microdiffraction data and Troy Carter (Abbott Vascular) for sectioning the scaffolds. This research used resources of the APS, a US Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract DE-AC02-06CH11357. This work was supported by Abbott Vascular, the Jacobs Institute for Molecular Engineering for Medicine, and the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award F31HL137308. Author contributions: K.R. and J.A.K. designed research; K.R. and T.D.L. performed research; A.A., M.B.K., and J.P.O. contributed new reagents/analytic tools; K.R. and J.A.K. analyzed data; and K.R. and J.A.K. wrote the paper. Conflict of interest statement: M.B.K. and J.P.O. are employees of Abbott Vascular. Funding for this research was provided by Abbott Vascular. This article is a PNAS Direct Submission. This article contains supporting information online at
Group:Jacobs Institute for Molecular Engineering for Medicine
Funding AgencyGrant Number
Department of Energy (DOE)DE-AC02-06CH11357
Abbott VascularUNSPECIFIED
Jacobs Institute for Molecular Engineering for MedicineUNSPECIFIED
NIH Postdoctoral FellowshipF31HL137308
Subject Keywords:PLLA | hydrolysis | coronary heart disease | BVS | X-ray microdiffraction
Issue or Number:41
PubMed Central ID:PMC6187115
Record Number:CaltechAUTHORS:20180918-095157859
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Official Citation:Crimping-induced structural gradients explain the lasting strength of poly l-lactide bioresorbable vascular scaffolds during hydrolysis. Karthik Ramachandran, Tiziana Di Luccio, Artemis Ailianou, Mary Beth Kossuth, James P. Oberhauser, Julia A. Kornfield. Proceedings of the National Academy of Sciences Oct 2018, 115 (41) 10239-10244; DOI: 10.1073/pnas.1807347115
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89697
Deposited By: George Porter
Deposited On:18 Sep 2018 17:22
Last Modified:07 Mar 2022 18:52

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