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Oblique-incidence spatially resolved diffuse reflectance spectroscopic diagnosis of skin cancer

Garcia-Uribe, Alejandro and Zou, Jun and Chang, Tzu-Hsuan and Duvic, Madeleine and Prieto, Victor and Wang, Lihong V. (2010) Oblique-incidence spatially resolved diffuse reflectance spectroscopic diagnosis of skin cancer. In: Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics. Proceedings of SPIE. No.7572. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 75720L. ISBN 9780819479686. https://resolver.caltech.edu/CaltechAUTHORS:20180918-140708183

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Abstract

This paper presents the use of spatially resolved oblique-incidence diffuse reflectance spectroscopy for skin cancer diagnosis. Spatio-spectral data from 166 pigmented skin lesions were collected for the wavelength range from 455 to 765 nm. A set of neural network based classifiers separates the pigmented malignant melanomas from the benign and dysplastic subgroups. A total of 110 lesions were used as the training set and 56 lesions were used as the testing set. This classifier performs with an overall 100% sensitivity and 92% specificity for the training set and 100% sensitivity and 88% specificity for the testing set. The second classifier was designed to separate the benign from the dysplastic subgroups. For the second classifier a total of 100 lesions were used as the training set and 51 lesions were used as the testing set. The overall classification rates were 94% and 88% for the training and testing sets respectively.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.842781DOIArticle
ORCID:
AuthorORCID
Zou, Jun0000-0002-9543-6135
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2010 Society of Photo-Optical Instrumentation Engineers (SPIE). The authors thank Dr. Mays, Dr. Hymens and Dr. Mansfield at the University of Texas M. D. Anderson Cancer Center for their help during the data collection. This project is sponsored by National Institute of Health grant R01 CA106728.
Funders:
Funding AgencyGrant Number
NIHR01 CA106728
Subject Keywords:diffuse reflectance, spectroscopy, skin cancer, melanoma
Series Name:Proceedings of SPIE
Issue or Number:7572
Record Number:CaltechAUTHORS:20180918-140708183
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180918-140708183
Official Citation:Alejandro Garcia-Uribe, Alejandro Garcia-Uribe, Jun Zou, Jun Zou, Tzu-Hsuan Chang, Tzu-Hsuan Chang, Madeleine Duvic, Madeleine Duvic, Victor Prieto, Victor Prieto, Lihong V. Wang, Lihong V. Wang, } "Oblique-incidence spatially resolved diffuse reflectance spectroscopic diagnosis of skin cancer", Proc. SPIE 7572, Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics, 75720L (25 February 2010); doi: 10.1117/12.842781; https://doi.org/10.1117/12.842781
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89710
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:19 Sep 2018 22:43
Last Modified:09 Mar 2020 13:19

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