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Molecular photoacoustic imaging using gold nanoparticles as a contrast agent

Kim, Chulhong and Cho, Eun Chul and Chen, Jingyi and Song, Kwang Hyun and Au, Leslie and Favazza, Christopher P. and Zhang, Qiang and Cobley, Claire M. and Xia, Younan and Wang, Lihong V. (2010) Molecular photoacoustic imaging using gold nanoparticles as a contrast agent. In: Photons Plus Ultrasound: Imaging and Sensing 2010. Proceedings of SPIE. No.7564. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 75641V. ISBN 9780819479600. http://resolver.caltech.edu/CaltechAUTHORS:20180918-140708286

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Abstract

Gold nanoparticles have received much attention due to their potential diagnostic and therapeutic applications. Gold nanoparticles are attractive in many biomedical applications because of their biocompatibility, easily modifiable surfaces for targeting, lack of heavy metal toxicity, wide range of sizes (35-100 nm), tunable plasmonic resonance peak, encapsulated site-specific drug delivery, and strong optical absorption in the near-infrared regime. Specifically, due to their strong optical absorption, gold nanoparticles have been used as a contrast agent for molecular photoacoustic (PA) imaging of tumor. The plasmonic resonance peak of the gold nanocages (AuNCs) was tuned to the near-infrared region, and the ratio of the absorption cross-section to the extinction cross-section was approximately ~70%, as measured by PA sensing. We used PEGylated gold nanocages (PEG-AuNCs) as a passive targeting contrast agent on melanomas. After 6-h intravenous injection of PEG-AuNCs, PA amplitude was increased by ~14 %. These results strongly suggest PA imaging paired with AuNCs is a promising diagnostic tool for early cancer detection.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.843549DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2010 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was supported in part by grants from National Institutes of Health (R01 EB000712, R01 EB008085, and U54 CA136398 -- the Network for Translational Research -- to L.V.W.). L.V.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. Y.X. thanks the National Institutes of Health for a 2006 Director’s Pioneer Award (DP1 OD000798-04). E.C.C. was also partially supported by a fellowship award from the Korea Research Foundation (KRF-2007-357-D00070) funded by the Korean Government. J.C. was supported by a Pilot Grant from Washington University Molecular Imaging Center.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 EB008085
NIHU54 CA136398
NIHDP1 OD000798-04
National Research Foundation of KoreaKRF-2007-357-D00070
Washington UniversityUNSPECIFIED
Subject Keywords:Photoacoustic tomography, molecular imaging, gold nanoparticles, B16 melanoma
Record Number:CaltechAUTHORS:20180918-140708286
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180918-140708286
Official Citation:Chulhong Kim, Chulhong Kim, Eun Chul Cho, Eun Chul Cho, Jingyi Chen, Jingyi Chen, Kwang Hyun Song, Kwang Hyun Song, Leslie Au, Leslie Au, Christopher P. Favazza, Christopher P. Favazza, Qiang Zhang, Qiang Zhang, Claire M. Cobley, Claire M. Cobley, Younan Xia, Younan Xia, Lihong V. Wang, Lihong V. Wang, } "Molecular photoacoustic imaging using gold nanoparticles as a contrast agent", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75641V (25 February 2010); doi: 10.1117/12.843549; https://doi.org/10.1117/12.843549
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89711
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:19 Sep 2018 22:46
Last Modified:19 Sep 2018 22:46

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