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Real-time monitoring of small animal cortical hemodynamics by photoacoustic tomography

Li, Changhui and Aquirre, Andres and Gamelin, John and Maurudis, Anastasios and Zhu, Quing and Wang, Lihong V. (2010) Real-time monitoring of small animal cortical hemodynamics by photoacoustic tomography. In: Photons Plus Ultrasound: Imaging and Sensing 2010. Proceedings of SPIE. No.7564. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 756427. ISBN 9780819479600. https://resolver.caltech.edu/CaltechAUTHORS:20180918-140708875

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Abstract

For the first time, the hemodynamics within the entire cerebral cortex of a mouse were studied by using photoacoustic tomography (PAT) non-invasively and in real time. The PAT system, based on a 512-element full-ring array with cylindrical focusing, received the PA signal primarily from a slice of about 2 mm thickness. This system can provide not only high resolution brain vasculature images but also hemodynamic functional images. We recorded the wash-in process of a photoacoustic contrast agent in a mouse brain in real time. Our results demonstrated that PAT is a powerful imaging modality to study real-time small animal neurofunctional activities that cause changes in hemodynamics.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.842159DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2010 Society of Photo-Optical Instrumentation Engineers (SPIE). We thank the Yu Wang and Junjie Yao for helpful discussions. This work has been supported in part by National Institutes of Health grants R01 EB000712, R01 EB008085, and U54 CA136398 (Network for Translational Research). L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 EB008085
NIHU54 CA136398
Subject Keywords:Photoacoustic imaging, hemodynamics, small animal imaging, neurofunctional imaging
Series Name:Proceedings of SPIE
Issue or Number:7564
Record Number:CaltechAUTHORS:20180918-140708875
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180918-140708875
Official Citation:Changhui Li, Changhui Li, Andres Aquirre, Andres Aquirre, John Gamelin, John Gamelin, Anastasios Maurudis, Anastasios Maurudis, Quing Zhu, Quing Zhu, Lihong V. Wang, Lihong V. Wang, } "Real-time monitoring of small animal cortical hemodynamics by photoacoustic tomography", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756427 (23 February 2010); doi: 10.1117/12.842159; https://doi.org/10.1117/12.842159
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89717
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:19 Sep 2018 23:18
Last Modified:03 Oct 2019 20:18

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