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Fast-scanning reflection-mode integrated photoacoustic and optical-coherence microscopy

Li, Li and Rao, Bin and Maslov, Konstantin and Wang, Lihong V. (2010) Fast-scanning reflection-mode integrated photoacoustic and optical-coherence microscopy. In: Photons Plus Ultrasound: Imaging and Sensing 2010. Proceedings of SPIE. No.7564. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 75641Z. ISBN 9780819479600.

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We previously demonstrated that multimodal microscopy combining photoacoustic microscopy and optical coherence tomography can provide comprehensive insight into biological tissue at μm-level resolution by exploiting both optical absorption and scattering contrasts. Recently, we have developed a second-generation integrated photoacoustic and optical-coherence microscope, which can potentially be adapted for clinical applications. In this new system, we can perform photoacoustic and optical-coherence imaging simultaneously at a speed of 5,000 A-lines per second with real-time on-screen display. Also, both modalities now work in reflection mode instead of transmission mode, allowing easy access to various anatomical locations of interest. Imaging of skin and eye has been demonstrated in living small animals.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
Rao, Bin0000-0001-6494-3110
Maslov, Konstantin0000-0003-3408-8840
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2010 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was supported by National Institutes of Health Grants R01 EB000712, R01 EB008085, R01 CA092415, and U54 CA136398. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 EB008085
NIHR01 CA092415
NIHU54 CA136398
Subject Keywords:Multimodal imaging, Photoacoustic imaging, Optical coherence tomography, Dermatology, Ophthalmology
Series Name:Proceedings of SPIE
Issue or Number:7564
Record Number:CaltechAUTHORS:20180918-140709139
Persistent URL:
Official Citation:Li Li, Li Li, Bin Rao, Bin Rao, Konstantin Maslov, Konstantin Maslov, Lihong V. Wang, Lihong V. Wang, } "Fast-scanning reflection-mode integrated photoacoustic and optical-coherence microscopy", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75641Z (23 February 2010); doi: 10.1117/12.843826;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89720
Deposited By: George Porter
Deposited On:19 Sep 2018 23:26
Last Modified:03 Mar 2020 13:01

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