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Transcranial photoacoustic tomography of the monkey brain

Nie, Liming and Huang, Chao and Guo, Zijian and Anastasio, Mark and Wang, Lihong V. (2012) Transcranial photoacoustic tomography of the monkey brain. In: Photons Plus Ultrasound: Imaging and Sensing 2012. Proceedings of SPIE. No.8223. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 82230L. ISBN 9780819488664. https://resolver.caltech.edu/CaltechAUTHORS:20180918-140709994

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Abstract

A photoacoustic tomography (PAT) system using a virtual point ultrasonic transducer was developed for transcranial imaging of monkey brains. The virtual point transducer provided a 10 times greater field-of-view (FOV) than finiteaperture unfocused transducers, which enables large primate imaging. The cerebral cortex of a monkey brain was accurately mapped transcranially, through up to two skulls ranging from 4 to 8 mm in thickness. The mass density and speed of sound distributions of the skull were estimated from adjunct X-ray CT image data and utilized with a timereversal algorithm to mitigate artifacts in the reconstructed image due to acoustic aberration. The oxygenation saturation (sO_2) in blood phantoms through a monkey skull was also imaged and quantified, with results consistent with measurements by a gas analyzer. The oxygenation saturation (sO_2) in blood phantoms through a monkey skull was also imaged and quantified, with results consistent with measurements by a gas analyzer. Our experimental results demonstrate that PAT can overcome the optical and ultrasound attenuation of a relatively thick skull, and the imaging aberration caused by skull can be corrected to a great extent.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.907060DOIArticle
ORCID:
AuthorORCID
Anastasio, Mark0000-0002-3192-4172
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). This research was supported by the National Institutes of Health (grants R01 EB010049, R01 CA134539, R01 EB000712, U54 CA136398, and R01 EB008085).
Funders:
Funding AgencyGrant Number
NIHR01 EB010049
NIHR01 CA134539
NIHR01 EB000712
NIHU54 CA136398
NIHR01 EB008085
Subject Keywords:Transcranial photoacoustic tomography, time-reversal image reconstruction
Series Name:Proceedings of SPIE
Issue or Number:8223
Record Number:CaltechAUTHORS:20180918-140709994
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180918-140709994
Official Citation:Liming Nie, Liming Nie, Chao Huang, Chao Huang, Zijian Guo, Zijian Guo, Mark Anastasio, Mark Anastasio, Lihong V. Wang, Lihong V. Wang, } "Transcranial photoacoustic tomography of the monkey brain", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82230L (23 February 2012); doi: 10.1117/12.907060; https://doi.org/10.1117/12.907060
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89730
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:19 Sep 2018 21:29
Last Modified:03 Oct 2019 20:18

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