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Ultrasonic encoding of diffused light: from optical imaging to light focusing in turbid media

Xu, Xiao and Lai, Puxiang and Liu, Honglin and Wang, Lihong V. (2012) Ultrasonic encoding of diffused light: from optical imaging to light focusing in turbid media. In: Photons Plus Ultrasound: Imaging and Sensing 2012. Proceedings of SPIE. No.8223. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 822324. ISBN 9780819488664.

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In optical scattering media such as biological tissue, light propagation is randomized by multiple scattering. Beyond one transport mean free path, where photon propagation is in the diffusive regime, direct light focusing becomes infeasible. The resulting loss of light localization poses serious challenge to optical imaging in thick scattering media. Ultrasound modulated optical tomography (UOT) combines high optical contrast and good ultrasonic resolution, and is therefore an ideal imaging modality for soft biological tissue. A variety of detection techniques have been developed in UOT in an effort to discriminate the ultrasonically encoded diffused light as the imaging signal. We developed a photorefractive crystal based detection system, which has the ability to image both the optical and acoustic properties of biological tissues. With the improved photorefractive crystal based detection, tissue-mimicking phantom samples as thick as 9.4 cm can be imaged. We further exploit the virtual source concept in UOT and combine it with optical time reversal to achieve diffusive light focusing into scattering media. Experimental implementation of this new technology is presented.

Item Type:Book Section
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Liu, Honglin0000-0003-2473-9056
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE).
Subject Keywords:Optical Imaging, Tissue Optics, Photorefractive Detection, Ultrasound-modulated Optical Tomography, Diffusive Light Focusing
Series Name:Proceedings of SPIE
Issue or Number:8223
Record Number:CaltechAUTHORS:20180918-140710797
Persistent URL:
Official Citation:Xiao Xu, Xiao Xu, Puxiang Lai, Puxiang Lai, Honglin Liu, Honglin Liu, Lihong V. Wang, Lihong V. Wang, } "Ultrasonic encoding of diffused light: from optical imaging to light focusing in turbid media", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 822324 (23 February 2012); doi: 10.1117/12.909916;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89740
Deposited By: George Porter
Deposited On:18 Sep 2018 23:20
Last Modified:09 Mar 2020 13:19

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