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Ring-shaped confocal photoacoustic computed tomography for small-animal whole-body imaging

Xia, Jun and Chatni, Muhammad and Maslov, Konstantin and Guo, Zijian and Anastasio, Mark and Wang, Lihong V. (2012) Ring-shaped confocal photoacoustic computed tomography for small-animal whole-body imaging. In: Photons Plus Ultrasound: Imaging and Sensing 2012. Proceedings of SPIE. No.8223. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 82230G. ISBN 9780819488664. https://resolver.caltech.edu/CaltechAUTHORS:20180918-140711130

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Abstract

We report herein a novel three-dimensional photoacoustic computed tomography (PACT) system for small-animal whole-body imaging. The PACT system, based on a 512-element full-ring ultrasonic transducer array, was cylindrically focused and capable of forming a two-dimensional image in 1.6 seconds. The pulsed laser could either illuminate directly from the top or be reshaped to illuminate the sample from the side. Top illumination was mainly used for mouse brain and mouse embryo imaging. Side illumination provided in vivo anatomical images of an adult mouse. By translating the mouse along the elevational direction, the system provided serial cross-sectional images.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.906056DOIArticle
ORCID:
AuthorORCID
Anastasio, Mark0000-0002-3192-4172
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was sponsored in part by National Institutes of Health grants R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 EB010049, R01 CA157277, R01 CA159959, and 5P60 DK02057933. L.W. has financial interests in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 EB008085
NIHR01 CA134539
NIHU54 CA136398
NIHR01 EB010049
NIHR01 CA157277
NIHR01 CA159959
NIH5P60 DK02057933
Subject Keywords:Photoacoustic computed tomography, small-animal imaging, whole-body imaging, focal-line image reconstruction
Series Name:Proceedings of SPIE
Issue or Number:8223
Record Number:CaltechAUTHORS:20180918-140711130
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180918-140711130
Official Citation:Jun Xia, Jun Xia, Muhammad Chatni, Muhammad Chatni, Konstantin Maslov, Konstantin Maslov, Zijian Guo, Zijian Guo, Mark Anastasio, Mark Anastasio, Lihong V. Wang, Lihong V. Wang, } "Ring-shaped confocal photoacoustic computed tomography for small-animal whole-body imaging", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82230G (23 February 2012); doi: 10.1117/12.906056; https://doi.org/10.1117/12.906056
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89744
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:18 Sep 2018 22:02
Last Modified:03 Oct 2019 20:18

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