CaltechAUTHORS
  A Caltech Library Service

Time-reversed ultrasonically encoded (TRUE) optical focusing in reflection mode: demonstrations in tissue mimicking phantoms and ex vivo tissue

Lai, Puxiang and Xu, Xiao and Liu, Honglin and Suzuki, Yuta and Wang, Lihong V. (2012) Time-reversed ultrasonically encoded (TRUE) optical focusing in reflection mode: demonstrations in tissue mimicking phantoms and ex vivo tissue. In: Photons Plus Ultrasound: Imaging and Sensing 2012. Proceedings of SPIE. No.8223. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 82231B. ISBN 9780819488664. https://resolver.caltech.edu/CaltechAUTHORS:20180918-140711507

[img] PDF - Published Version
See Usage Policy.

1716Kb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20180918-140711507

Abstract

The problem of how to effectively deliver light dynamically to a small volume inside turbid media has been intensively investigated for imaging and therapeutic purposes. Most recently, a new modality termed Time-Reversed Ultrasonically Encoded (TRUE) optical focusing was proposed by integrating the concepts of ultrasound modulation of diffused light with optical phase conjugation. In this work, the diffused photons that travel through the ultrasound focal region are "tagged" with a frequency shift due to the ultrasound modulation. Part of the tagged light is collected in reflection mode and transmitted to a photorefractive crystal, forming there a stationary hologram through interference with a coherent reference optical beam. The hologram is later read by a conjugated optical beam, generating a phase conjugated wavefront of the tagged light. It is conveyed back to the turbid medium in reflection mode, and eventually converges to the ultrasound focal zone. Optical focusing effects from this system are demonstrated experimentally in tissue-mimicking phantoms and ex vivo chicken breast tissue, achieving effective round-trip optical penetration pathlength (extinction coefficient multiplied by round-trip focusing depth) exceeding 160 and 100, respectively. Examples of imaging optical inclusions with this system are also reported.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.906017DOIArticle
ORCID:
AuthorORCID
Liu, Honglin0000-0003-2473-9056
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). This research is sponsored in part by the National Academies Keck Futures Initiative grant IS 13 and the National Institute of Health through grants R01 EB000712 and U54 CA136398. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
National Academies Keck Futures InitiativeIS 13
NIHR01 EB000712
NIHU54 CA136398
Subject Keywords:optical focusing, optical imaging, ultrasound modulation, optical phase conjugation, phase conjugation mirror, time reversal, photorefractive crystal, reflection mode, tissue-mimicking phantom, biological tissue, optical fiber bundle
Series Name:Proceedings of SPIE
Issue or Number:8223
Record Number:CaltechAUTHORS:20180918-140711507
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180918-140711507
Official Citation:Puxiang Lai, Puxiang Lai, Xiao Xu, Xiao Xu, Honglin Liu, Honglin Liu, Yuta Suzuki, Yuta Suzuki, Lihong V. Wang, Lihong V. Wang, } "Time-reversed ultrasonically encoded (TRUE) optical focusing in reflection mode: demonstrations in tissue mimicking phantoms and ex vivo tissue", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82231B (9 February 2012); doi: 10.1117/12.906017; https://doi.org/10.1117/12.906017
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89748
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:18 Sep 2018 21:51
Last Modified:09 Mar 2020 13:19

Repository Staff Only: item control page