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Functional photoacoustic microscopy of pH

Chatni, Muhammad Rameez and Yao, Junjie and Danielli, Amos and Favazza, Christopher P. and Maslov, Konstantin I. and Wang, Lihong V. (2011) Functional photoacoustic microscopy of pH. Journal of Biomedical Optics, 16 (10). Art. No. 100503. ISSN 1083-3668. PMCID PMC3210191. https://resolver.caltech.edu/CaltechAUTHORS:20180918-140711597

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Abstract

pH is a tightly regulated indicator of metabolic activity. In mammalian systems, an imbalance of pH regulation may result from or result in serious illness. In this paper, we report photoacoustic microscopy (PAM) of a commercially available pH-sensitive fluorescent dye (SNARF-5F carboxylic acid) in tissue phantoms. We demonstrated that PAM is capable of pH imaging in absolute values at tissue depths of up to 2.0 mm, greater than possible with other forms of optical microscopy.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/1.3644495DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210191/PubMed CentralArticle
http://resolver.caltech.edu/CaltechAUTHORS:20180918-140711236Related ItemConference Paper
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). Paper 11186LRR received Apr. 12, 2011; revised manuscript received Aug. 24, 2011; accepted for publication Sep. 9, 2011; published online Oct. 14, 2011. The authors thank James Ballard and Sandra Matteucci for help in manuscript edition. This work was supported in part by National Institutes of Health Grant Nos. U54CA136398 and R01 EB000712. L. V. Wang has a financial interest in Microphotoacoustics, Inc. and Endra, Inc, which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHU54 CA136398
NIHR01 EB000712
Subject Keywords:photoacoustic microscopy; pH imaging; SNARF-5F carboxylic acid
Issue or Number:10
PubMed Central ID:PMC3210191
Record Number:CaltechAUTHORS:20180918-140711597
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180918-140711597
Official Citation:Mohammad R. Chatni, Mohammad R. Chatni, Junjie Yao, Junjie Yao, Amos Danielli, Amos Danielli, Christopher P. Favazza, Christopher P. Favazza, Konstantin I. Maslov, Konstantin I. Maslov, Lihong V. Wang, Lihong V. Wang, } "Functional photoacoustic microscopy of pH," Journal of Biomedical Optics 16(10), 100503 (1 October 2011). https://doi.org/10.1117/1.3644495 .
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89749
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:18 Sep 2018 21:46
Last Modified:03 Oct 2019 20:18

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