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In vivo functional human imaging using photoacoustic microscopy: response to ischemic and thermal stimuli

Favazza, Christopher and Maslov, Konstantin and Cornelius, Lynn and Wang, Lihong V. (2010) In vivo functional human imaging using photoacoustic microscopy: response to ischemic and thermal stimuli. In: Photons Plus Ultrasound: Imaging and Sensing 2010. Proceedings of SPIE. No.7564. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 75640Z. ISBN 9780819479600. https://resolver.caltech.edu/CaltechAUTHORS:20180919-160039051

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Abstract

We report results of two in vivo functional human imaging experiments using photoacoustic microscopy. In Experiment 1, the hemodynamic response to an ischemic event was measured. The palm of a volunteer was imaged and a single cross-section was monitored while periodic arterial occlusions were administered using a blood pressure cuff wrapped around the upper arm and inflated to ~280 mmHg. Significant relative decreases in oxygen saturation (sO_2) and total hemoglobin (HbT) were observed during periods of ischemia. Upon release of the occlusion, significant relative increases in sO_2 and HbT due to post-occlusive reactive hyperemia were recorded. Experiment 2 explored the vascular response to a local, external thermal stimulus. Thermal hyperemia is a common physiological phenomenon and thermoregulation function in which blood flow to the skin is increased to more efficiently exchange heat with the ambient environment. The forearm of a volunteer was imaged and a single cross-section was monitored while the imaged surface was exposed to an elevated temperature of ~46°C. Due to thermal hyperemia, relative increases in sO_2 and HbT were measured as the temperature of the surface was raised. These results may contribute as clinically relevant measures of vascular functioning for detection and assessment of vascular related diseases.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.841975DOIArticle
ORCID:
AuthorORCID
Maslov, Konstantin0000-0003-3408-8840
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2010 Society of Photo-Optical Instrumentation Engineers (SPIE). This research was supported by National Institutes of Health grants R01 EB000712, 5 T32 AR07284, R01 EB008085, R01 CA113453901, and U54 CA136398. LW acknowledges financial interest in Endra Inc., which, however, did not support this research.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIH Predoctoral Fellowship5 T32 AR07284
NIHR01 EB008085
NIHR01 CA113453901
NIHU54 CA136398
Subject Keywords:photoacoustic microscopy, reactive hyperemia, microcirculation
Series Name:Proceedings of SPIE
Issue or Number:7564
Record Number:CaltechAUTHORS:20180919-160039051
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180919-160039051
Official Citation:Christopher Favazza, Christopher Favazza, Konstantin Maslov, Konstantin Maslov, Lynn Cornelius, Lynn Cornelius, Lihong V. Wang, Lihong V. Wang, } "In vivo functional human imaging using photoacoustic microscopy: response to ischemic and thermal stimuli", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75640Z (23 February 2010); doi: 10.1117/12.841975; https://doi.org/10.1117/12.841975
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89763
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:20 Sep 2018 15:30
Last Modified:03 Mar 2020 13:01

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