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Invasive and transcranial photoacoustic imaging of the vascular response to brain electrical stimulation

Tsytsarev, Vassiliy and Yao, Junjie and Hu, Song and Li, Li and Favazza, Christopher P. and Maslov, Konstantin I. and Wang, Lihong V. (2010) Invasive and transcranial photoacoustic imaging of the vascular response to brain electrical stimulation. In: Photons Plus Ultrasound: Imaging and Sensing 2010. Proceedings of SPIE. No.7564. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 756407. ISBN 9780819479600. http://resolver.caltech.edu/CaltechAUTHORS:20180919-160039616

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Abstract

Advances in the brain functional imaging greatly facilitated the understanding of neurovascular coupling. For monitoring of the microvascular response to the brain electrical stimulation in vivo we used optical-resolution photoacoustic microscopy (OR-PAM) through the cranial openings as well as transcranially. Both types of the vascular response, vasoconstriction and vasodilatation, were clearly observed with good spatial and temporal resolution. Obtained results confirm one of the primary points of the neurovascular coupling theory that blood vessels could present vasoconstriction or vasodilatation in response to electrical stimulation, depending on the balance between inhibition and excitation of the different parts of the elements of the neurovascular coupling system.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.840290DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2010 Society of Photo-Optical Instrumentation Engineers (SPIE). The authors thank Dr. Alexey Glukhov for technical support, and Prof. Sandra Matteucci for help in editing the manuscript. This work was supported by National Institutes of Health Grants R01 EB000712, R01 NS46214, R01 EB008085, R01 CA113453901, and U54 CA136398. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 NS46214
NIHR01 EB008085
NIHR01 CA113453901
NIHU54 CA136398
Subject Keywords:brain imaging, vasoconstriction, vasodilatation, brain electrical stimulation, optical-resolution photoacoustic microscopy
Record Number:CaltechAUTHORS:20180919-160039616
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180919-160039616
Official Citation:Vassiliy Tsytsarev, Vassiliy Tsytsarev, Junjie Yao, Junjie Yao, Song Hu, Song Hu, Li Li, Li Li, Christopher P. Favazza, Christopher P. Favazza, Konstantin I. Maslov, Konstantin I. Maslov, Lihong V. Wang, Lihong V. Wang, } "Invasive and transcranial photoacoustic imaging of the vascular response to brain electrical stimulation", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756407 (23 February 2010); doi: 10.1117/12.840290; https://doi.org/10.1117/12.840290
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89768
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:20 Sep 2018 16:29
Last Modified:20 Sep 2018 16:29

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