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Quantification of optical absorption coefficients from acoustic spectra with photoacoustic tomography

Guo, Zijian and Hu, Song and Favazza, Christopher P. and Erpelding, Todd N. and Jankovic, Ladislav and Wang, Lihong V. (2011) Quantification of optical absorption coefficients from acoustic spectra with photoacoustic tomography. In: Photons Plus Ultrasound: Imaging and Sensing 2011. Proceedings of SPIE. No.7899. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 78990W. ISBN 9780819484369.

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Optical absorption is closely associated with many physiologically important parameters, such as the concentration and oxygen saturation of hemoglobin, and it can be used to quantify the concentrations of non-fluorescent molecules. We introduce a method to quantify the absolute optical absorption based upon the acoustic spectra of photoacoustic (PA) signals. This method is self-calibrating and thus insensitive to variations in optical fluence. Factors such as the detection system bandwidth and acoustic attenuation can affect the quantification but can be canceled by measuring the acoustic spectra at two optical wavelengths. This method has been implemented on various PA systems, including optical-resolution PA microscopy, acoustic-resolution PA microscopy, and reconstruction based PA array systems. We quantified the optical absorption coefficients of phantom samples at various wavelengths. We also quantified the oxygen saturation of hemoglobin in live mice.

Item Type:Book Section
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Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).
Subject Keywords:Photoacoustic tomography, acoustic spectrum, optical absorption coefficient, blood oxygen saturation
Series Name:Proceedings of SPIE
Issue or Number:7899
Record Number:CaltechAUTHORS:20180920-130933539
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Official Citation:Zijian Guo, Zijian Guo, Song Hu, Song Hu, Christopher P. Favazza, Christopher P. Favazza, Todd N. Erpelding, Todd N. Erpelding, Ladislav Jankovic, Ladislav Jankovic, Lihong V. Wang, Lihong V. Wang, } "Quantification of optical absorption coefficients from acoustic spectra with photoacoustic tomography", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78990W (17 February 2011); doi: 10.1117/12.875015;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89791
Deposited By: George Porter
Deposited On:21 Sep 2018 15:29
Last Modified:03 Oct 2019 20:19

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