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Three-dimensional photoacoustic imaging with a clinical two-dimensional matrix ultrasound transducer

Erpelding, Todd N. and Wang, Yu and Jankovic, Ladislav and Guo, Zijian and Robert, Jean-Luc and David, Guillaume and Kim, Chulhong and Wang, Lihong V. (2011) Three-dimensional photoacoustic imaging with a clinical two-dimensional matrix ultrasound transducer. In: Photons Plus Ultrasound: Imaging and Sensing 2011. Proceedings of SPIE. No.7899. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 78990A. ISBN 9780819484369. https://resolver.caltech.edu/CaltechAUTHORS:20180920-130933714

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Abstract

Photoacoustic tomography provides both structural and functional imaging in vivo based on optical absorption contrast. A novel imaging system that incorporates a two-dimensional matrix ultrasound probe for combined photoacoustic and ultrasonic three-dimensional (3D) volumetric imaging is presented. The system consists of a tunable dye laser pumped by a Nd:YAG laser, a commercial ultrasound imaging system (Philips iU22) with a two-dimensional matrix transducer (Philips X7-2, 2500 elements, 2-7 MHz), and a multichannel data acquisition system which allows us to acquire RF channel data. Compared with alternative 3D techniques, this system is attractive because it can generate co-registered 3D photoacoustic and ultrasound images without mechanical scanning. Moreover, the lateral resolution along the azimuth and elevational directions are measured to be 0.77 ± 0.06 mm and 0.96 ± 0.06 mm, respectively, based on reconstructed photoacoustic images of phantoms containing individual human hairs. Finally, in vivo 3D photoacoustic sentinel lymph node mapping using methylene blue dye in a rat model is demonstrated.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.875169DOIArticle
ORCID:
AuthorORCID
Wang, Yu0000-0003-3589-9274
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). This research was supported by National Institutes of Health grants U54 CA136398 (Network for Translational Research), R01 EB000712, R01 NS46214, and R01 EB008085. LVW has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. TNE, LJ, and JR are employees of Philips Research.
Funders:
Funding AgencyGrant Number
NIHU54 CA136398
NIHR01 EB000712
NIHR01 NS46214
NIHR01 EB008085
Subject Keywords:photoacoustic imaging, ultrasound, matrix ultrasound transducer, three-dimensional imaging, sentinel lymph node
Series Name:Proceedings of SPIE
Issue or Number:7899
Record Number:CaltechAUTHORS:20180920-130933714
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180920-130933714
Official Citation:Todd N. Erpelding, Todd N. Erpelding, Yu Wang, Yu Wang, Ladislav Jankovic, Ladislav Jankovic, Zijian Guo, Zijian Guo, Jean-Luc Robert, Jean-Luc Robert, Guillaume David, Guillaume David, Chulhong Kim, Chulhong Kim, Lihong V. Wang, Lihong V. Wang, } "Three-dimensional photoacoustic imaging with a clinical two-dimensional matrix ultrasound transducer", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78990A (17 February 2011); doi: 10.1117/12.875169; https://doi.org/10.1117/12.875169
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89793
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:21 Sep 2018 15:13
Last Modified:09 Mar 2020 13:19

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