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Three-dimensional photoacoustic imaging with a clinical two-dimensional matrix ultrasound transducer

Erpelding, Todd N. and Wang, Yu and Jankovic, Ladislav and Guo, Zijian and Robert, Jean-Luc and David, Guillaume and Kim, Chulhong and Wang, Lihong V. (2011) Three-dimensional photoacoustic imaging with a clinical two-dimensional matrix ultrasound transducer. In: Photons Plus Ultrasound: Imaging and Sensing 2011. Proceedings of SPIE. No.7899. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 78990A. ISBN 9780819484369.

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Photoacoustic tomography provides both structural and functional imaging in vivo based on optical absorption contrast. A novel imaging system that incorporates a two-dimensional matrix ultrasound probe for combined photoacoustic and ultrasonic three-dimensional (3D) volumetric imaging is presented. The system consists of a tunable dye laser pumped by a Nd:YAG laser, a commercial ultrasound imaging system (Philips iU22) with a two-dimensional matrix transducer (Philips X7-2, 2500 elements, 2-7 MHz), and a multichannel data acquisition system which allows us to acquire RF channel data. Compared with alternative 3D techniques, this system is attractive because it can generate co-registered 3D photoacoustic and ultrasound images without mechanical scanning. Moreover, the lateral resolution along the azimuth and elevational directions are measured to be 0.77 ± 0.06 mm and 0.96 ± 0.06 mm, respectively, based on reconstructed photoacoustic images of phantoms containing individual human hairs. Finally, in vivo 3D photoacoustic sentinel lymph node mapping using methylene blue dye in a rat model is demonstrated.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
Wang, Yu0000-0003-3589-9274
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). This research was supported by National Institutes of Health grants U54 CA136398 (Network for Translational Research), R01 EB000712, R01 NS46214, and R01 EB008085. LVW has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. TNE, LJ, and JR are employees of Philips Research.
Funding AgencyGrant Number
NIHU54 CA136398
NIHR01 EB000712
NIHR01 NS46214
NIHR01 EB008085
Subject Keywords:photoacoustic imaging, ultrasound, matrix ultrasound transducer, three-dimensional imaging, sentinel lymph node
Series Name:Proceedings of SPIE
Issue or Number:7899
Record Number:CaltechAUTHORS:20180920-130933714
Persistent URL:
Official Citation:Todd N. Erpelding, Todd N. Erpelding, Yu Wang, Yu Wang, Ladislav Jankovic, Ladislav Jankovic, Zijian Guo, Zijian Guo, Jean-Luc Robert, Jean-Luc Robert, Guillaume David, Guillaume David, Chulhong Kim, Chulhong Kim, Lihong V. Wang, Lihong V. Wang, } "Three-dimensional photoacoustic imaging with a clinical two-dimensional matrix ultrasound transducer", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78990A (17 February 2011); doi: 10.1117/12.875169;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89793
Deposited By: George Porter
Deposited On:21 Sep 2018 15:13
Last Modified:09 Mar 2020 13:19

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