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Integrated photoacoustic and fluorescence confocal microscopy

Wang, Yu and Maslov, Konstantin and Kim, Chulhong and Hu, Song and Wang, Lihong V. (2011) Integrated photoacoustic and fluorescence confocal microscopy. In: Photons Plus Ultrasound: Imaging and Sensing 2011. Proceedings of SPIE. No.7899. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 78990M. ISBN 9780819484369. https://resolver.caltech.edu/CaltechAUTHORS:20180920-130934333

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Abstract

Optical-resolution photoacoustic microscopy has demonstrated utility in imaging and characterizing microvasculature networks in vivo. This work presents a novel imaging system that integrates optical-resolution photoacoustic microscopy and fluorescence confocal microscopy for simultaneous photoacoustic and fluorescence imaging. The integrated system can acquire intrinsically registered photoacoustic and fluorescence images in a single scan. Capable of providing micrometer scale microscopic imaging of both optical absorption and fluorescence contrasts, the system demonstrates in vivo imaging of oxygen saturation and oxygen partial pressure in mouse ears.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.874888DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). We thank C. Zhang for helping with data processing and manuscript preparation, and Professor J. Ballard for careful proofreading. This work was sponsored in part by National Institutes of Health (NIH) grants R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, and 5P60 DK02057933. L. Wang has a financial interest in Microphotoacoustics, Inc., and Endra, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 EB008085
NIHR01 CA134539
NIHU54 CA136398
NIH5P60 DK02057933
Subject Keywords:Photoacoustic microscopy, fluorescence confocal microscopy, oxygen saturation, oxygen partial pressure
Series Name:Proceedings of SPIE
Issue or Number:7899
Record Number:CaltechAUTHORS:20180920-130934333
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180920-130934333
Official Citation:Yu Wang, Yu Wang, Konstantin Maslov, Konstantin Maslov, Chulhong Kim, Chulhong Kim, Song Hu, Song Hu, Lihong V. Wang, Lihong V. Wang, } "Integrated photoacoustic and fluorescence confocal microscopy", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78990M (17 February 2011); doi: 10.1117/12.874888; https://doi.org/10.1117/12.874888
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89800
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:20 Sep 2018 22:28
Last Modified:03 Oct 2019 20:19

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