CaltechAUTHORS
  A Caltech Library Service

Quantitative high-resolution photoacoustic spectroscopy by combining photoacoustic imaging with diffuse optical tomography

Bauer, Adam Q. and Nothdurft, Ralph E. and Erpelding, Todd N. and Wang, Lihong V. and Culver, Joseph P. (2011) Quantitative high-resolution photoacoustic spectroscopy by combining photoacoustic imaging with diffuse optical tomography. In: Photons Plus Ultrasound: Imaging and Sensing 2011. Proceedings of SPIE. No.7899. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 78993O. ISBN 9780819484369. https://resolver.caltech.edu/CaltechAUTHORS:20180920-130935097

[img] PDF - Published Version
See Usage Policy.

409Kb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20180920-130935097

Abstract

The specificity of both molecular and functional photoacoustic (PA) images depends on the accuracy of the photoacoustic absorption spectroscopy. Because the PA signal is a product of both the optical absorption coefficient and the local light fluence, quantitative PA measurements of absorption require an accurate estimate of the optical fluence. Lightmodeling aided by diffuse optical tomography (DOT) methods can be used to provide the required fluence map and to reduce errors in traditional PA spectroscopic analysis. As a proof-ofconcept, we designed a phantom to demonstrate artifacts commonly found in photoacoustic tomography (PAT) and how fluence-related artifacts in PAT images can lead to misrepresentations of tissue properties. Specifically, we show that without accounting for fluence-related inhomogeneities in our phantom, errors in estimates of the absorption coefficient from a PAT image were as much as 33%. To correct for this problem, DOT was used to reconstruct spatial distributions of the absorption coefficients of the phantom, and along with the surface fluence distribution from the PAT system, we calculated the fluence everywhere in the phantom. This fluence map was used to correct PAT images of the phantom, reducing the error in the estimated absorption coefficient from the PAT image to less than 5%. Thus, we demonstrate experimentally that combining DOT with PAT can significantly reduce fluence-related errors in PAT images, as well as produce quantitatively accurate, highresolution images of the optical absorption coefficient.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.875549DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was supported in part by NIH grant R01-EB008085.
Funders:
Funding AgencyGrant Number
NIHR01-EB008085
Series Name:Proceedings of SPIE
Issue or Number:7899
Record Number:CaltechAUTHORS:20180920-130935097
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180920-130935097
Official Citation:Adam Q. Bauer, Adam Q. Bauer, Ralph E. Nothdurft, Ralph E. Nothdurft, Todd N Erpelding, Todd N Erpelding, Lihong V. Wang, Lihong V. Wang, Joseph P. Culver, Joseph P. Culver, } "Quantitative high-resolution photoacoustic spectroscopy by combining photoacoustic imaging with diffuse optical tomography", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78993O (28 February 2011); doi: 10.1117/12.875549; https://doi.org/10.1117/12.875549
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89808
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:20 Sep 2018 20:19
Last Modified:03 Oct 2019 20:19

Repository Staff Only: item control page