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Deep reflection-mode photoacoustic imaging and resolution scalability with depth

Song, Kwang Hyun and Wang, Lihong V. (2007) Deep reflection-mode photoacoustic imaging and resolution scalability with depth. In: Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. Proceedings of SPIE. No.6437. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 643722. ISBN 9780819465504. https://resolver.caltech.edu/CaltechAUTHORS:20180921-100901651

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Abstract

A deep reflection-mode photoacoustic (PA) imaging system was designed and implemented to visualize deep structures in biological tissues. To achieve good penetration depth, we chose near IR laser pulses at 804 nm wavelength for the generation of photoacoustic waves. To avoid overshadowing the deep PA signals by the surface PA signals, we employed dark-field illumination. To achieve good lateral resolution, we chose spherically focused high-numerical-aperture ultrasonic transducers with 5 MHz or 10 MHz center frequencies. By using these transducers, we achieved 153 μm and 130 μm axial resolutions, respectively, at 19.5 mm depth in 10% porcine gelatin containing 1% intralipid. The system was applied to imaging internal organs of small animals. Compared with our previous high-frequency (50-MHz) photoacoustic microscope, we scaled up the imaging depth while maintaining the ratio of the imaging depth to axial resolution more than 100. In addition, we studied the scalability of the imaging depth and the resolution with ultrasound frequency.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.698823DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2007 Society of Photo-Optical Instrumentation Engineers (SPIE). We thank Konstantine Maslov, Xinmai Yang for fruitful laboratory assistance. The project sponsored by National Institutes of Health grants R01 CA106728 and R01 NS46214 (BRP).
Funders:
Funding AgencyGrant Number
NIHR01 CA106728
NIHR01 NS46214
Subject Keywords:deep, reflection-mode, photoacoustic, brain cortex, kidney
Series Name:Proceedings of SPIE
Issue or Number:6437
DOI:10.1117/12.698823
Record Number:CaltechAUTHORS:20180921-100901651
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180921-100901651
Official Citation:Kwang Hyun Song, Kwang Hyun Song, Lihong V. Wang, Lihong V. Wang, } "Deep reflection-mode photoacoustic imaging and resolution scalability with depth", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 643722 (13 February 2007); doi: 10.1117/12.698823; https://doi.org/10.1117/12.698823
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89827
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:27 Sep 2018 15:12
Last Modified:16 Nov 2021 00:38

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