CaltechAUTHORS
  A Caltech Library Service

High-resolution burn imaging in pig skin by photoacoustic microscopy

Zhang, Hao F. and Maslov, Konstantin and Stoica, George and Wang, Lihong V. (2007) High-resolution burn imaging in pig skin by photoacoustic microscopy. In: Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. Proceedings of SPIE. No.6437. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 64370A. ISBN 9780819465504. https://resolver.caltech.edu/CaltechAUTHORS:20180921-100901921

[img] PDF - Published Version
See Usage Policy.

685kB

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20180921-100901921

Abstract

Existing noninvasive imaging modalities fail to provide high-resolution depth-resolved imaging of skin burns in large depths. Hence, the measurement of burn depth, especially for partial-thickness burn, remains inaccurate. We used photoacoustic microscopy to measure the depth of acute thermal burns by imaging the microvasculature damage. In this work, partial-thickness burns were induced in vivo on pig skin. Limited by the flexibility of the photoacoustic scanning system, photoacoustic images of the burns were acquired after skin excision. Experimental results show that burn depth increases with longer heating duration. The maximum imaged burn depth measures ∼1.7 mm with a depth resolution of 15 µm.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.698005DOIArticle
ORCID:
AuthorORCID
Maslov, Konstantin0000-0003-3408-8840
Stoica, George0000-0001-8071-4828
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2007 Society of Photo-Optical Instrumentation Engineers (SPIE). We thank Dr. Geng Ku and Xueyi Xie for experimental assistance. This project is sponsored by National Institutes of Health grants R01 EB000712 and R01 NS46214.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 NS46214
Subject Keywords:Burn, microvasculature, photoacoustic, microscopy
Series Name:Proceedings of SPIE
Issue or Number:6437
DOI:10.1117/12.698005
Record Number:CaltechAUTHORS:20180921-100901921
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180921-100901921
Official Citation:Hao F. Zhang, Hao F. Zhang, Konstantin Maslov, Konstantin Maslov, George Stoica, George Stoica, Lihong V. Wang, Lihong V. Wang, } "High-resolution burn imaging in pig skin by photoacoustic microscopy", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 64370A (13 February 2007); doi: 10.1117/12.698005; https://doi.org/10.1117/12.698005
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89830
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:26 Sep 2018 22:35
Last Modified:16 Nov 2021 00:38

Repository Staff Only: item control page