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Adaptive and robust techniques (ART) for thermoacoustic and photoacoustic tomography

Xie, Yao and Guo, Bin and Li, Jian and Ku, Geng and Wang, Lihong V. (2007) Adaptive and robust techniques (ART) for thermoacoustic and photoacoustic tomography. In: Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. Proceedings of SPIE. No.6437. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 643715. ISBN 9780819465504.

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In this paper, we present new Adaptive and Robust Techniques (ART) for microwave-based thermoacoustic tomography (TAT) and laser-based photo-acoustic tomography (PAT), and study their performances for breast cancer detection. TAT and PAT are emerging medical imaging techniques that combine the merits of high contrast due to electromagnetic or laser stimulation and high resolution offered by thermal acoustic imaging. The current image reconstruction methods used for TAT and PAT, such as the widely used Delay-and-Sum (DAS) approach, are data-independent and suffer from low resolution, high sidelobe levels, and poor interference rejection capabilities. The data-adaptive ART can have much better resolution and much better interference rejection capabilities than their data-independent counterparts. By allowing certain uncertainties, ART can be used to mitigate the amplitude and phase distortion problems encountered in TAT and PAT. Specifically, in the first step of ART, RCB is used for waveform estimation by treating the amplitude distortion with an uncertainty parameter. In the second step of ART, a simple yet effective peak searching method is used for phase distortion correction. Compared with other energy or amplitude based response intensity estimation methods, peak searching can be used to improve image quality with little additional computational costs. Moreover, since the acoustic pulse is usually bipolar: a positive peak, corresponding to the compression pulse, and a negative peak, corresponding to the rarefaction pulse, we can further enhance the image contrast in TAT or PAT by using the peak-to-peak difference as the response intensity for a focal point. The excellent performance of ART is demonstrated using both simulated and experimentally measured data.

Item Type:Book Section
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Li, Jian0000-0003-0297-6528
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2007 Society of Photo-Optical Instrumentation Engineers (SPIE). This research was supported in part by the National Institutes of Health (NIH) Grant No. 1R41CA107903-1.
Funding AgencyGrant Number
Subject Keywords:Thermoacoustic Tomography, Adaptive and Robust Techniques
Series Name:Proceedings of SPIE
Issue or Number:6437
Record Number:CaltechAUTHORS:20180921-100902463
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Official Citation:Yao Xie, Yao Xie, Bin Guo, Bin Guo, Jian Li, Jian Li, Geng Ku, Geng Ku, Lihong V. Wang, Lihong V. Wang, } "Adaptive and robust techniques (ART) for thermoacoustic and photoacoustic tomography", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 643715 (13 February 2007); doi: 10.1117/12.698391;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89835
Deposited By: George Porter
Deposited On:24 Sep 2018 16:32
Last Modified:16 Nov 2021 00:38

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